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Novel Insights into Apoptosis Pathways and Autoimmune Diseases

Our new model reveals the complex interplay between apoptosis pathways and autoimmune diseases. Understand the role of anti-apoptotic protein TCTP, Bcl-xL, and cytosolic Bax translocation. Explore the impact of irradiation, cytotoxic drugs, viruses, bacteria, and more on cell death pathways.

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Novel Insights into Apoptosis Pathways and Autoimmune Diseases

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  1. Our new model of the interplay between apoptosis pathways: Anti-apoptotic protein TCTP interacts with Bcl-xL and sequesters cytosolic Bax translocation into mitochondria Irradiation Cytotoxic drugs Virus Bacteria Growth factor & cytokine removal anoikis Death receptors: FasL, TNFR, DR3, DR4/5 FADD or TRADD DISC Bcl-2/Bcl-xL Pro-caspase 8 tBID TCTP caspase 8 Sensors microtubules Pro-caspase 3 casposome Dm Bax mitochondria BH3 only/Bax translocation Cytochrome c Active caspase 3 Caspase cascade Apaf-1/ Caspase 9 (apoptosome) Nucleus Apoptosis Yang et al., Oncogene 24, 4778, 2005

  2. Our new model of selection of autoantigens: Stimulation-responsive splicing of autoantigen transcripts plays an important role in triggering pathogenesis of autoimmune diseases Ng et al., J. Allergy Clin. Immunol. 114, 1463, 2004; Xiong et al., J. Clin. Pathol, in press, 2006

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