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Ion Channels: Foundations of Electricity in Biological Systems

Learn how ion channels act as pores in the cell membrane, affecting capacitance, voltage response, and cell size. Dive into Electron and Ohm's Laws, Nernst and Goldman Equations, and their implications on ion channel properties. Explore the analogous components of a biological membrane in a basic circuit.

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Ion Channels: Foundations of Electricity in Biological Systems

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  1. Ion Channels as pores…..

  2. High capacitance of the PL bilayer is attributed to the small length of the H-C chains (space between the parallel plates).

  3. Basic Electricity to Understand Biological Signals

  4. The outer shell – loss or gain of electrons is the foundation of Electronic Theory What are the analogous biological membrane components for a basic circuit?

  5. Electron Theory Positive to Negative is the convention attributed to Ben Franklin, yet is not reality

  6. Ohm’s Law is most widely used physical law in electrophysiology

  7. Which is the biological circuit? Why?

  8. The Membrane As a Capacitor

  9. How does the capacitance affect the voltage response? How do you calculate capacitance? How can capacitance determine size of the cell?

  10. Potential difference driven by ion composition and ATPase pumps

  11. The Nernst Equation

  12. The Goldman Equation

  13. What Do Current Voltage Relationships Tell us about Selectivity and Ion Channel Properties?

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