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CLiC Spring Workshop 2008 Will duct tape cure my warts? Complementary and Alternative Medicine Resources February 26, 2008 Dana Abbey, MLS National Network of Libraries of Medicine [email protected] Developed by the National Network of Libraries of Medicine South Central Region Objectives

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developed by the national network of libraries of medicine south central region
CLiC Spring Workshop 2008

Will duct tape cure my warts?Complementary and Alternative Medicine ResourcesFebruary 26, 2008Dana Abbey, MLSNational Network of Libraries of [email protected]

Developed by the

National Network of Libraries of Medicine

South Central Region

objectives
Objectives
  • Have knowledge of the definition and types of Complementary and Alternative Medicine (CAM)
  • Have greater knowledge of the history of CAM and it's impact on medical practice
  • Have greater understanding of usage of CAM
  • Increase confidence in evaluating health websites
  • Increase skills in avoiding “bad science” found on the Internet or in the news
  • Become more proficient in searching for evidence of the effectiveness of CAM
agenda
Agenda
  • Definitions
  • History and Impact
  • Usage and Therapies
  • Evaluating Web Sites
  • Avoiding Bad Science
  • Recommended Websites
  • Reviewing the Evidence
how do you get rid of a wart
garlic pills

cabbage

alfalfa pills

How do you get rid of a wart?

castor oil

banana peel

iodine

toothpaste

Windex

potato

nail polish

raw meat

duct tape

silk thread

witch hazel

dandelion juice

cigarette ashes

aloe

apple cider

orange peel

quarters

assess your knowledge of cam
Assess Your Knowledge of CAM

The Food and Drug Administration (FDA) regulates dietary supplements.

Partially true: as of June 2007 the FDA requires good manufacturing practices (GMP) of supplements

Chiropractic care is still considered a type of CAM therapy.

True: it is a manipulative and body-based practice

Manufacturers need to register a dietary supplement with the FDA before producing it.

False: unless it contains a “new dietary ingredient” (an ingredient not marketed before October 1999)

Although CAM is gaining in popularity, to date there have been no clinical trials conducted on this type of therapy.

False: there are nearly 40,000 CAM clinical trials referenced in PubMed

what is cam
What is CAM?
  • Complementary and Alternative Medicine

CAM is a group of diverse medical and health care systems, practices, and products that are not presently considered to be part of conventional medicine (NCCAM)

  • Complementary: together with
    • aromatherapy to help with pain after surgery
  • Alternative: in place of
    • using garlic to lower blood pressure
  • “A comprehensive health care program which we now call ‘integrative care,’ which incorporates the best of conventional evidence-based Western bioscience with evidence-based complementary therapies.”

David Eisenberg, M.D. Director of the Division for Research and Education in Complementary and Integrative Medical Therapies and the Osher Institute at Harvard Medical School)

cam becomes legit
CAM becomes “legit”
  • 1990
    • Wilk et al v. AMA
  • 1991
    • NIH Office of Alternative Medicine established
  • 1992
    • Chantilly Workshop/Report
  • 1994
    • Dietary Supplement Health and Education Act
cam becomes legit9
CAM becomes “legit”
  • 1995
    • NIH Office of Dietary Supplements http://ods.od.nih.gov/
    • FDA declassifies Acupuncture needles as experimental product
  • 1996
    • NIH Consensus Conference on Acupuncture
  • 1997
    • First large trial of CAM therapy, St. John’s Wort for depression
  • 1998
    • National Center for Complementary & Alternative Medicine (NCCAM) established
    • First full scale article in JAMA on herbal medicine
      • “Trends in alternative medicine use in the United States, 1990-1997: results of a follow-up national survey”
    • Office of Cancer Complementary and Alternative Medicine (OCCAM)
cam becomes legit10
CAM becomes “legit”
  • 2001
    • CAM on PubMed (NCCAM and NLM)
  • 2004
    • Effectiveness of acupuncture as adjunctive therapy in osteoarthritis of the knee: a randomized, controlled trial
  • 2007
    • FDA Issues Dietary Supplements Final Rule
    • FDA Draft of Evidence-Based Review System for Scientific Evaluation of Health Claims
impact of cam
Impact of CAM
  • CDC Report (2004)*
    • 36% of adults used some form of CAM
    • 55% CAM + conventional treatments
    • 26% used CAM because a medical professional suggested it
    • $36-47 billion on CAM therapies in 1997
    • $5 billion on herbal remedies
  • Alternative Therapies (2007)+
    • Nearly 1 in 5 of U.S. population use herbal medicine (more than half did not disclose this information to their physicians)

*Barnes PM, et al. Complementary and alternative medicine use among adults: United States 2002; CDC

+Gardiner P, et al. Factors Associated with Herbal Therapy Use By Adults in the United States. Alternative Therapies in Health and Medicine. 2007 Mar-Apr

who uses herbal medicine
Who Uses Herbal Medicine?*
  • Largely non-Hispanic white
  • 35-54 years old
  • Self-perceived health status excellent, very good or good
  • Majority use both herbal and prescription
  • Female
  • Higher education levels
  • Have medical insurance
  • Visited health professional in the last 6 months

* Gardiner P, et al.

diseases and conditions
2004*

Back pain or problem

Head or chest cold

Neck pain or problem

Joint pain or stiffness

Anxiety/depression

Arthritis, gout, lupus or fibromyalgia

Stomach or intestinal illness

Severe headache or migraine

Recurring Pain

Insomnia

2007+

Head or chest cold

Musculoskeletal conditions (back, neck, arthritis, gout, lupus, fibromyalgia)

Stomach or intestinal illness

Anxiety/depression

Insomnia

Severe headache/migraine

Menopause

Cholesterol

Recurring pain

Diseases and Conditions*

*Barnes PM, et al.

+Gardiner P, et al.

top cam therapies
Top CAM Therapies*
  • Prayer
  • Natural products, dietary supplements
  • Deep breathing exercises
  • Meditation
  • Chiropractic
  • Yoga
  • Massage
  • Diets

*Barnes PM, et al.

top 10 supplements
2004*

Echinacea

Ginseng

Ginkgo biloba

Garlic

Glucosamine

St. John’s wort

Peppermint

Fish oil/Omega 3

Ginger

Soy

2007+

Echinacea

Ginseng

Ginkgo biloba

Garlic

St. John’s wort

Peppermint

Ginger

Soy

Ragweed

Kava kava

Top 10 Supplements

*Barnes PM, et al.

+Gardiner P, et al.

categorization of therapies
Categorization of Therapies*
  • Whole Medical Systems
  • Biologically Based Practices
  • Energy Medicine
  • Manipulative and Body-Based Practices
  • Mind-Body Medicine

*National Center of Complementary and Alternative Therapy

whole medical systems
Whole Medical Systems
  • Complete systems of theory and practice that evolved independently from conventional medicine
  • Traditional systems of medicine that are practiced by individual cultures throughout the world
    • Includes acupuncture, traditional Chinese medicine, Ayurvedic medicine, homeopathy, naturopathy

*National Center of Complementary and Alternative Therapy

biologically based practices
Biologically Based Practices
  • Includes: botanicals, animal-derived extracts, vitamins, minerals, fatty acids, amino acids, proteins, whole diets, and functional foods
    • Dietary supplements are a subset of biologically based practices

*National Center of Complementary and Alternative Therapy

biologically based supplements
Biologically Based - Supplements
  • What is a supplement?
  • Regulated by FDA http://www.fda.gov
    • no requirements for FDA testing
    • manufacturers responsible for ensuring product safety
    • label requirements
    • safety alerts: http://www.cfsan.fda.gov/~dms/ds-warn.html
energy medicine
Energy Medicine
  • Veritable - energy that can be measured
    • Includes sound, visible light, magnetism
  • Putative – energy that has yet to be measured
    • human beings are infused with a subtle form of energy
    • Includes qi (ki in Japanese); doshas; prana, homeopathic resonance

*National Center of Complementary and Alternative Therapy

energy medicine acupuncture
Energy Medicine - Acupuncture
  • Few complications
  • Scientific evidence?
    • post chemotherapy management of nausea
    • pain relief
  • NIH Consensus Statement (1997)
    • http://consensus.nih.gov/1997/1997Acupuncture107html.htm
manipulative and body based
Manipulative and Body-Based
  • Structures and systems of the body, including the bones and joints, the soft tissues, and the circulatory and lymphatic systems
    • Includes chiropractic manipulation, massage therapy, reflexology, rolfing, Alexander technique,Feldenkrais method

*National Center of Complementary and Alternative Therapy

mind body medicine
Mind-Body Medicine
  • Interactions among the brain, mind, body, and behavior
  • The ways in which emotional, mental, social, spiritual, and behavioral factors can directly affect health
    • Includes relaxation, hypnosis, visual imagery, meditation, yoga, biofeedback, tai chi, group support, and spirituality

*National Center of Complementary and Alternative Therapy

cam therapies
CAM Therapies

In 1992, “complementary therapies” introduced in MeSH

avoiding bad science
Avoiding Bad Science
  • The “One Product Does It All” claim

http://www.emuoilcanada.com/

  • Personal Testimonials http://www.getslimslippers.com/
  • Quick Fixes/Cures

http://www.cure-your-asthma.com

  • The “No Risk Money Back Guarantee” http://www.bodycatalyst.com/colon_cleanse.html
  • The “Natural” claim

http://www.amtrueman.com/products.html

evaluating web sites
Evaluating Web Sites
  • Accuracy
  • Authority
  • Bias
  • Currency
  • Coverage
examining the research
Examining the Research
  • Observational Studies
    • a study that does not involve randomization but where available data are nonetheless analyzed to make treatment comparisons. Observational studies are subject to bias, which may render their conclusions less reliable than those obtained by well controlled randomized CLINICAL TRIALS. Still, they may be useful for hypothesis generation and defining the natural history of disease.
  • Clinical Trials/Studies
    • Types of Trials
      • Treatment
      • Prevention
      • Diagnostic
      • Screening
      • Quality of life
    • Phases
      • Phase I- test experimental drug/treatment on 20-80 people for the 1st time
      • Phase II- experimental drug/treatment on 100-300 people for effectiveness and safety
      • Phase III- experimental drug/treatment on 1,000-3,000 people to monitor side effects
      • Phase IV- post-marketing studies to garner more information on risk, benefits, and use
examining the research28
Examining the Research
  • Clinical Trials/Studies
    • Randomized: A method based on chance by which study participants are assigned to a treatment group. Randomization minimizes the differences among groups by equally distributing people with particular characteristics among all the trial arms. The researchers do not know which treatment is better.
    • Blind: A randomized trial is "Blind" if the participant is not told which arm of the trial he is on. A clinical trial is "Blind" if participants are unaware on whether they are in the experimental or control arm of the study; also called masked.
    • Double-blind: A clinical trial design in which neither the participating individuals nor the study staff knows which participants are receiving the experimental drug and which are receiving a placebo (or another therapy). Double-blind trials are thought to produce objective results, since the expectations of the doctor and the participant about the experimental drug do not affect the outcome; also called double-masked study.
examining the research29
Examining the Research
  • Bias
    • When a point of view prevents impartial judgment on issues relating to the subject of that point of view. In clinical studies, bias is controlled by blinding and randomization
  • ClinicalTrials.gov
    • Gov’t and private clinical studies involving humans
    • Developed under Federal mandate in 1997
    • http://clinicaltrials.gov
    • Contains 51,509 trials conducted nationwide and in 153 countries
    • Receives over 20 million page hits per day
    • 34,000 daily visitors
reviewing the evidence
Reviewing the Evidence
  • Evidence Based Medicine: “What evidence do we have to justify the treatment…”
  • MedlinePlus
    • Over 100 Herbal Supplements Monographs: Validated rating scales are used to evaluate the quality of available evidence.
    • Complimentary and Alternative Therapies
  • PubMed
    • CAM on PubMed used by researchers, CAM practitioners, health care providers, students, people with illnesses, their family and friends, advocacy organizations, and many others as a resource to find citations related to complementary and alternative medicine
    • there are over 506,149 citations in the CAM subset of PubMed (from 1966 forward)
  • National Center for Complementary and Alternative Medicine (NCCAM)
so will duct tape cure my warts
So, Will Duct Tape Cure My Warts?
  • 2002 Study
    • Randomized control trial (duct tape vs. liquid nitrogen)
    • 51 out of 61 patients completed study
    • Ages 3-22 years
    • 85% of duct tape patients vs. 60% of cryotherapy had complete resolution of warts
  • 2007 Study
    • Double-blind randomized control trial (mole skin with duct tape vs. mole skin)
    • 80 out of 90 patients completed study
    • Median age 54
    • Found no statistically significant difference in treatment
links
Links
  • Class Links
    • http://nnlm.gov/training/consumer/cam/cam-classlinks.html
  • Recommended Sites
    • http://nnlm.gov/training/consumer/cam/cam-recommend.doc
  • CAM on PubMed Workbook
    • http://nnlm.gov/training/consumer/cam/cam-pubmed.pdf
  • Website Evaluation Exercises
    • http://nnlm.gov/training/consumer/cam/cam-evalwebsites.doc
  • Class Exercises
    • http://nnlm.gov/training/consumer/cam/cam-exercises.doc
bibliography
Bibliography
  • Barnes PM, Powell-Griner E, McFann K, Nahin RL. Complementary and alternative medicine use among adults: United States, 2002. Advance data from vital and health statistics; no 343. Hyattsville, Maryland: National Center for Health Statistics. 2004 http://nccam.nih.gov/news/report.pdf (free)
  • Gardiner P, Graham R, Legedza A, Ahn A, Eisenberg D, Phillips R. Factors Associated with Herbal Therapy Use By Adults in the United States. Alternative Therapies in Health and Medicine. 2007 Mar-Apr; 13 (2): 22-29. http://www.alternative-therapies.com/at/
  • Focht D, Spicer C, Faircock M. Efficacy of Duct Tape vs Cryotherapy in the Treatment of Verruca Vulgaris (the Common Wart). Archives of Pediatrics & Adolescent Medicine. 2002; Oct; 156 (10): 971-974. http://archpedi.ama-assn.org/cgi/content/abstract/156/10/971
  • Institute of Medicine Committee on the Use of Complementary and Alternative Medicine by the American Public. National Academies Press 2005 http://www.nap.edu/books/0309092701/html/
  • Marbella AM, Harris MC, Diehr S, Ignace G, Ignace G. Use of Native American healers among Native American patients in an urban Native American health center. Arch Fam Med. 1998 Mar-Apr;7(2):182-5. http://archfami.ama-assn.org/cgi/content/full/7/2/182 (free)
  • Werner R, Askari S, Cham P, Kedrowski D, Liu A, Warshaw E. Duct Tape for the Treatment of Common Warts in Adults. Archives of Dermatology. 2007 Mar; 143: 309-313. http://archderm.ama-assn.org/cgi/content/abstract/143/3/309
dana abbey mls national network of libraries of medicine midcontinental region

Dana Abbey, MLSNational Network of Libraries of Medicine-MidContinental Region

[email protected]://nnlm.gov/mcr/

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