T Cell Maturation and Activation February 15, 2001 Outline T Cell Maturation Early development in the thymus Positive Selection and Negative Selection CD4 + T Cells vs. CD8 + T Cells T Cell Activation Signal Transduction/Gene Expression Costimulation Expansion vs. Anergy
February 15, 2001
(Bone Marrow Thymus Periphery)
Positive Selection Negative Selection No T Cells?
CD4+ T Cells vs. CD8+ T Cells - 2 Models...