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Transmissible Severity of NASH in ASC-Deficient Mice: Role of Intestinal Inflammation

This study explores how the increased severity of NASH in ASC-deficient mice is transmitted to db/db mice through co-housing, highlighting the role of CCL5-induced intestinal inflammation. The research sheds light on the mechanisms of NASH progression and the impact of gut inflammation on metabolic disorders.

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Transmissible Severity of NASH in ASC-Deficient Mice: Role of Intestinal Inflammation

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  1. Increased severity of NASH in Asc-deficient mice is transmissible to db/db by co-housing and is mediated by CCL5-induced intestinal inflammation. J Henao-Mejia et al. Nature000, 1-7 (2012) doi:10.1038/nature10809

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