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Bone Mineral Density and Fracture

Bone Mineral Density and Fracture. The Plot Thickens: The Bones Thin. New Use(s)?. Thigh bone connected to the blood stream Flexibility, strength and balance Custom models. Both Ends against the Middle. Argument for Impact:

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Bone Mineral Density and Fracture

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  1. Bone Mineral Density and Fracture

  2. The Plot Thickens: The Bones Thin

  3. New Use(s)? • Thigh bone connected to the blood stream • Flexibility, strength and balance • Custom models

  4. Both Ends against the Middle • Argument for Impact: Mechanical stress activates osteocytes • Argument against Impact: Trauma initiates chondral degeneration

  5. Osteoporosis and Osteoarthritis • Osteoarthritis • Mechanoreceptors: Impact a must. • Osteoporosis • Chondral Damage: No Impact.

  6. Osteoporosis vs Osteoarthritis • Osteoarthritis • Mechanoreceptors: Impact a must. • Osteoporosis • Chondral Damage: No Impact.

  7. Osteoporosis and Osteoarthritis • Bone arises from cartilage: Bone Both Cartilage

  8. A Sliver Lining

  9. Chondroblasts and ‘Clasts

  10. Chondrocytes are Family Practitioners

  11. Dynamic Support System

  12. Feedback system • Architectonic reflects lines of stress • Buildup of bone reduces deformation • Osteoporosis should increase response

  13. Competitive Physiology “Static loading does not prevent osteoporosis” • Rubin, CT, Lanyon, LE, Baust, G: “Modulation of bone loss during calcium insufficiency by controlled dynamc load.” Calcif Tis Int 1986;38:209-216.

  14. Turkey wings lead the wayCompetitive Physiology “Static loading does not prevent osteoporosis” “Short periods of dynamic loading protect the bones in calcium-deficiency.” • Rubin, CT, Lanyon, LE, Baust, G: “Modulation of bone loss during calcium insufficiency by controlled dynamc load.” Calcif Tis Int 1986;38:209-216.

  15. Turkey wings lead the way • 3H uridine rises six-fold after loading1 • 8 seconds of loading = prevention2 • 72 seconds of loading > 30% - 40%2 • Nothing more with 720 or 3600 seconds2 • 1. Pead, MJ, Suswillo, R, Skerry, TM et al: “Increased 3H uridine levels in osteocytes following a single short period of dynamic bone loading in vivo.” Calcif Tisue Int 1988;43:93-97. • 2. Rubin, CT, Lanyon, LE: “Regulation of bone formation by applied dynamic loads. J Bone Joint Surg 1984;66A:397-402.

  16. Turkey wings lead the way Eccentric pulls on periostium increase bone strength, reversing osteoporosis Lanyon, L.E. “Osteoporosis and exercise.” Topics in Geriatric Rehabilitation. March 1989 4:(2)pp.12- 24.

  17. Woolf, J: The Law of Bone Transformation. Berlin, A. Hirschwald, 1892. Deforming force

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