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A Rational and Attainable Approach to Successfully Implementing Biosafety in Laboratory Settings Worldwide. Anticipating Biosecurity Challenges of the Global Expansion of High Containment Biological Laboratories Istanbul, Turkey 11-13 July 2011 Barbara Johnson PhD, RBP

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A Rational and Attainable Approach to Successfully Implementing Biosafety in Laboratory Settings Worldwide.

Anticipating Biosecurity Challenges of the Global Expansion of High Containment Biological Laboratories

Istanbul, Turkey

11-13 July 2011

Barbara Johnson PhD, RBP

Biosafety Biosecurity International

biosafety challenges
Biosafety Challenges
  • Lack of funding
  • Lack of reliable/maintained infrastructure
  • Lack of containment equipment
  • Supply shortages/delayed shipments
  • Lack of training
  • Other?

Regardless of these challenges the public health, medical, and R&D mission continues.

bsl 3 practices enhance safety
BSL-3 Practices Enhance Safety
  • Training and proficiency: good practices prevent exposure
  • Control access to the lab: limit people in lab during work
  • Reducing community spread: designated lab over-clothes stay in the lab; should be decontaminated & laundered by the institute
bsl 3 practices enhance safety1
BSL-3 Practices Enhance Safety
  • Autoclave availability and power: Can we flame loops outside the BSC and place them in a sterile can in the BSC
  • Sharps cause many lab injuries: Puncture-proof containers near point ofuse ;alternatives to commercial containers
  • Waste decontamination options: autoclave, chemical, burn
  • Reducing spill hazard: reusable/sealable container for within-room and room-to-room transport
primary containment considerations
Primary Containment Considerations
  • BSC: cost, space & power bumps are a reality.
  • Q: Is it infectious via the aerosol route???
    • risk appropriate PPE (respirator/mask, face shield/goggles/gloves)... respirator reuse?
    • cleaning surfaces and equipment
    • can a ‘fan box’ (inward airflow, no HEPA) be vented to outside, pilot ongoing in Africa
    • flexible film isolators for higher aerosol hazards
adapting bsl 3 design features
Adapting BSL-3 Design Features
  • Gas decontamination v surface wipe down for rooms and spaces with i.e. bleach
  • Directional airflow: place wall mounted exhaust fan at end of hall or inside the ‘lab with greatest hazards’
  • Single-pass air or recirculate air from BSL-3???
    • Air is not recirculated to lower containment levels- assess the risk (can it be HEPA filtered?)
    • WHO LBM and CDC/NIH BMBL
adapting bsl 3 design features1
Adapting BSL-3 Design Features
  • Air changes/hr
    • 10-12 was based on labs w/volatile chemicals
    • new minimum = 6 ACH for BSL-3 labs (could be less -depends on heat load, activities, is specific to the lab)
  • Night, weekend, holiday: decrease the conditioning of the air/lights to reduce expense
    • the lab really should not be ‘turned off’ – overheating, mold, condensation
adapting bsl 3 design features2
Adapting BSL-3 Design Features
  • N+1 systems: are they needed/which are needed
    • Systems and parts- local manufacture and installers; expertise is nearby, spares are available
  • Turnkey container labs: identify mission needs
    • a clean room with lots of HEPAs = $$ and overkill
    • HEPAs need to be annually certified
    • can exhaust air be vented away from public spaces and supply inlets (no re-entrainment)
no only one correct way

Practices / Protocols

Facilities

Equipment

No “Only One Correct Way”...

Biosafety is about risk assessment and planning:

  • prioritize the goals & needs
  • achieve it by balancing the available tools to reduce risk
  • plan ahead for accident, illness or injury
thank you
Thank You

Barbara Johnson, PhD, RBP

703-444-5028

barbara_johnson@verizon.net