Hpatitis A. Hepatitis A is a highly contagious liver infection caused by the hepatitis A virus. Hepatitis A is one of several types of hepatitis viruses that cause inflammation that affects the functions of the live.
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Hepatitis A is a highly contagious liver infection caused by the hepatitis A virus.
Hepatitis A is one of several types of hepatitis viruses that cause inflammation that affects the functions of the live.
Every year, approximately 10 million people worldwide are infected with the virus.
The hepatitis virus is usually spread when a person ingests tiny amounts of contaminated fecal matter.
The hepatitis A virus infects the liver cells and causes inflammation. The inflammation can impair liver function and cause other signs and symptoms of hepatitis A.
Hepatitis A signs and symptoms typically don't appear until you've had the virus for a month. Signs and symptoms of hepatitis A include:
Nausea and vomiting
Abdominal pain or discomfort, especially in the area of your liver on your right side beneath your lower ribs
Loss of appetite
Yellowing of the skin and eyes (jaundice)
Signs and symptoms of hepatitis A usually last less than two months, but may last as long as six months. Not everyone with hepatitis A develops signs or symptoms.
You're at increased risk of hepatitis A if you:
Travel or work in regions with high rates of hepatitis A
Are a man who has sexual contact with other men
Use injected or noninjected illicit drugs
Live with another person who has hepatitis A
Receive clotting-factor concentrates for hemophilia or another medical condition
IN VARIOUS BODY FLUIDS
Infectious Doses per mL
Source: Viral Hepatitis and Liver Disease 1984;9-22
J Infect Dis 1989;160:887-890
Blood tests are used to detect the presence of hepatitis A in the body. A sample of blood is taken, usually from a vein in the arm, and sent to a laboratory for testing.
signs and symptoms
No specific treatment exists for hepatitis A. Your body will clear the hepatitis A virus on its own. In most cases of hepatitis A, the liver heals completely in a month or two with no lasting damage.
Hepatitis A treatment usually focuses on coping with signs and symptoms of hepatitis A infection. For instance:
Expect to have less energy. Many people with hepatitis A infection feel tired and have less energy for their daily tasks. Rest when you need to. You may need several days off work or school in order to recover.
Find ways to cope with nausea. Nausea can make it difficult to eat. Find ways to make food more appealing. Eat small snacks throughout the day, rather than three large meals. Try soft, easily digested foods, such as soup or broth, yogurt and toast, as these may be the most appealing.
Incubation period 30-40 daysAcute, self limiting hepatitis, no chronic carrier stateAge: predominantly young adults, 15-40 years
Similar to hepatitis A; virus replicates in the gut initially, before invading the liver, and virus is shed in the stool prior to the onset of symptoms.Viraemia is transient. A large inoculum of virus is needed to establish infection.
No routine laboratory tests are available as yet. Virus cannot be cultured in vitro.
The most characterisitc markers of infection are the serum aminotransferases
Get as much rest as you can while your body fights off the virus.
Subunit HEV vaccines
The direct intramuscular injection of purified plasmid DNA containing the full-length ORF2 of HEV has induced a prolonged humoral immune response
To the expressed structural protein ORF2 in 80% and 100% of two separate groups of challenged mice, respectively