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2003-2004 Immunopharmacology

2003-2004 Immunopharmacology. 5 November 2014 9:18 AM. Alemtuzumab. Antineoplastic Anti-CD52 antibody. Aminoglutethimide. Antineoplastic Immunosuppressive Glucocorticoid antagonist Aromatase inhibitor (decreases steroid synthesis). Anti-thymocyte globulin. Immunosuppressive

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2003-2004 Immunopharmacology

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  1. 2003-2004Immunopharmacology 5 November 20149:18 AM

  2. Alemtuzumab • Antineoplastic • Anti-CD52 antibody

  3. Aminoglutethimide • AntineoplasticImmunosuppressive • Glucocorticoid antagonistAromatase inhibitor(decreases steroid synthesis)

  4. Anti-thymocyte globulin • Immunosuppressive • Anti-T cell antibody

  5. Azathioprine • ImmunosuppressiveAntineoplastic • Antimetabolite(“pseudofeedback inhibition” of HGPRT and PRP)

  6. Basiliximab • Immunosuppressive • Anti-CD25 (interleukin 2 receptor) Organ transplant (antirejection)

  7. Cyclosporine • ImmunosuppressiveAntineoplastic • Binds cyclophilinInhibits calcineurin

  8. Daclizumab • Immunosuppressive • Anti-CD25 (interleukin 2 receptor) antibody Organ transplant (anti-rejection)

  9. Dexamethasone • AdrenocorticosteroidGlucocorticoidAntineoplastic • Anti-inflammatory steroidNot by inhalation

  10. Ibritumomab • Antineoplastic • Anti-CD20 antibody

  11. Interferon alpha • Antiviral for hepatitisAntineoplasticCytokine • Anti-angiogenesis

  12. Interleukin 2 • Cytokine Antineoplastic

  13. Interleukin 11 • Cytokine Antineoplastic (supporting agent)

  14. Methotrexate • ImmunosuppressiveAntineoplastic • Folic acid antagonistDihydrofolate reductase inhibitor

  15. Muromonab-CD3 • Immunosuppressive • Mouse monoclonal anti-CD3 antibody Organ transplant (anti-rejection)

  16. Mycophenolate • Immunosuppressive • Inhibits inosine monophosphate dehydrogenase activity

  17. Palivizumab • Antiviral • Monoclonal antibody againstthe surface ofrespiratory syncytial virus

  18. Rituxumab • Antineoplastic • Anti-CD20 antibody

  19. Sirolimus Rapamycin • Immunosuppressive • Binds FKBP, inhibits mTOR (mammalian kinase target of rapamycin) & cell cycle progression

  20. Tacrolimus • ImmunosuppressiveAntineoplastic • Binds FKBP (FK506 binding protein)Inhibits calcineurin

  21. Trastuzumab • Antineoplastic • Anti-HER2 antibody

  22. Tumor necrosis factor  • CytokineAntineoplastic

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