METERED DOSE INHALER. Presented by: Aarohi Shah M.Pharam. Department of Pharmaceutics and Pharmaceutical Technology L.M. College of Pharmacy. We shall discuss:. Advantages of Nasal Route as systemic delivery Limitations Anatomy of respiratory tract Metered Dose inhalers design
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Department of Pharmaceutics and Pharmaceutical Technology
L.M. College of Pharmacy
Mucociliary blanketAnatomy of respiratory tract
Retard evaporation of the spray, which increases oropharyngeal drug deposition and reduce respirable aerosol fraction.
Chemical instability of drug
Extraction from valve rubber seal
e.g. CFC (chlorofluorocarbons),
e.g. N2, CO2
e.g., HCFCs 22,142b, and 152a
Hydrofluroalkanes (HFA) are chlorine-free and are judged to have zero ODP. HFA-134a is an important promising replacent for CFC-12
(1) Rapid impact “slugging”
(2) Precision deep-drawing – Uniform wall thickness, greater strength.
(1) Cold Filling
(2) Pressure Filling
(3) Under Cup Filling
(1) Suspension aids – to increase the number of compounds that can be prepared as high quality suspensions.
(2) Solubilizers – to enable solution formation at high doses.
(3) Sustained release agents – to enhance lung residence time of the compound.
Drug particles are not distinguished from excipients.
Sampling may not be representative of the whole sample.
Assumption: the particles are spherical and of equal density.
Light Scattering Counters
Ability to deliver therapeutic proteins and peptides
Sustained drug delivery
Improved shelf life
β2- Adrenoreceptor Agonist