Background Information for “Toxicity Testing with California Blackworms and Alcohol” Created by Stefani D. Hines with modifications by Debbie Gevirtzman, SWEHSC, University of Arizona. INTRODUCTION TO TOXICOLOGY. What is it? How is it used?. Toxicology .
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Inhalation – chemicals can be breathed into the lungs
Absorption - chemicals can enter the body by moving through the skinRoutes of Entry
Measured in mg of chemical/kg or lb of weightDose
Weight: 125 lb 135 lb 20 lb 5 lb
Tylenol: 300 mg 600 mg 100 mg 50 mg
50 mg 5 lb = 10 mg/lb
300 mg 125 lb = 2.4 mg/lb
Paracelsus, 1493-1541The Dose Makes The Poison
Most hazardous substances exhibit a “dose-response” relationship. What does this mean?
A. The harm caused by the hazard increases as the amount of hazard entering the body (dose) increases.
B. It does not matter how big a dose you receive, you will always have the same amount of harm/sickness.
C. Exposure to the hazard always results in harm.
Chronic Toxicity– a small dose of a toxicant over a long period of timeToxicity