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Programmable and Autonomous Computing Machine Made of Biomolecules

Programmable and Autonomous Computing Machine Made of Biomolecules. Y. Benenson, T.Paz-Elizur, E. Keinan, Z. Livneh and E. Shapiro Nature , v.414, 22 Nov. 2000, pp.430-434 Summarized by Lee, In-hee. Introduction. Constructed finite automaton Hardware Class IIS restriction nuclease FokI

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Programmable and Autonomous Computing Machine Made of Biomolecules

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  1. Programmable and Autonomous Computing Machine Made of Biomolecules Y. Benenson, T.Paz-Elizur, E. Keinan, Z. Livneh and E. Shapiro Nature, v.414, 22 Nov. 2000, pp.430-434 Summarized by Lee, In-hee

  2. Introduction • Constructed finite automaton • Hardware • Class IIS restriction nuclease FokI • T4 DNA ligase • ATP • Software • Eight ds DNA molecules (transition molecules) • ds DNA encoding initial state and input • Two output detection molecules

  3. Operation

  4. Operation

  5. Experiment

  6. Summary • 109 transitions per second • Energy consumption rate 10-10 W • Complexity is bounded by number of non-palindromic sticky ends

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