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MUTATIONS. What is a gene mutation?. During replication (in DNA), an error may be made that causes changes in the mRNA and proteins made from that part of the DNA These errors or changes are called mutations There are three possible outcomes when DNA sequences change: An improvement

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Presentation Transcript
what is a gene mutation
What is a gene mutation?
  • During replication (in DNA), an error may be made that causes changes in the mRNA and proteins made from that part of the DNA
  • These errors or changes are called mutations
  • There are three possible outcomes when DNA sequences change:
    • An improvement
    • No change at all
    • A harmful change
types of gene mutations
Types of Gene Mutations
  • Pointmutation:
    • changes in only 1 or a few nucleotides of DNA
    • Substitution – a point mutation, in which one base changes

Point mutation resulting in Sickle Cell Anemia

types of gene mutations1
Types of Gene Mutations
  • Frameshift mutation:
    • one base is deleted (deletion) or added (insertion) into a DNA sequence
    • Causes the entire sequence of codons to shift over by one base

Types of

Mutations

what are chromosomal mutations
What are Chromosomal Mutations?
  • Mutations involving deletions and insertions within a long segment of DNA
    • Inversion occurs within the same chromosome
    • Chromosomal rearrangement occurs between different chromosomes

Chromosomal inversion

Causes of mutations

why are mutations important
Why are mutations important?
  • Mutations in DNA cause changes in the sequence of amino acids, which ultimately creates changes in proteins and their function.

Mutations &

Enzymes

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