Key Physiologic Points About Pregnancy • Cardiac output and blood volume increase during pregnancy. • Pregnant women have an increased Pa O2 and decreased Pa CO2
Key Physiologic Points About Pregnancy • Pregnant women have an increased GFR. • Pregnant women have altered drug pharmacokinetics.
Vaginal deliveries are safer than cesarean sections, even in women with medical problems.
Drug Safety • Drug safety classifications for pregnancy are not as helpful as a careful consideration of both the potential risks of a medication and its potential benefits for a given clinical situation. • ACE inhibitors, tetracycline, and the flouroquinolones are almost never indicated.
General internists have an important role to play in the care of the pregnant woman with medical problems. • Help is also available from obstetricians, maternal fetal medicine, and obstetric medicine.