Automated Selection of Patients for Clinical Trials. Eugene Fink Lawrence O. Hall Dmitry B. Goldgof Bhavesh D. Goswami Matthew Boonstra Jeffrey P. Krischer. Clinical trials. A clinical trial is an evaluation of a new treatment procedure.
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Eugene FinkLawrence O. HallDmitry B. GoldgofBhavesh D. GoswamiMatthew Boonstra
Jeffrey P. Krischer
A clinical trial is an evaluationof a new treatment procedure.
When physicians conduct a trial, theyrecruit patients with matching healthproblems and medical histories.
The selection of trial participants isa manual procedure, and physiciansmay miss eligible patients.
We have developed a system thatautomatically selects prospectivetrial participants.
The knowledge base includes a list
of medical tests. A test descriptionincludes a dollar cost and relatedquestions about a patient’s health.
Mammogram, $150What is the cancer stage?Does the patient have invasive cancer?
Biopsy, $400How many lymph nodes have tumor cells?What is the greatest tumor diameter?
The system collects data until it candetermine whether the eligibilityexpressions are TRUE or FALSE.
If patient records do not provideenough data, the system identifiesthe required medical tests.
We have used fifteen breast-cancertrials at the Moffitt Cancer Center.
The results suggest that the systemcan increase the number of trialparticipants by a factor of three.
The selection of trial participantsmay require medical tests.
The system chooses the ordering of teststhat reduces their expected total cost.
After getting the results of the first test, itrevises the ordering of the remaining tests.
The ordering is based on the test costs,number of trials that require each test,and structure of eligibility expressions.
We have developed a system thatselects prospective trial participants.