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Understanding axon guidance is crucial for the ability of growing axons to navigate through the complex landscape of a developing embryo to reach their correct target tissues and establish synaptic communication. Growing axons recognize molecules on surfaces as cues, responding differently to cues based on developmental stages, leading to different outputs. Pioneer axon navigation, chemoattraction at the CNS midline, and cytoskeletal remodeling play vital roles in axon guidance. Mechanisms such as activation of DCC by netrins, upregulation of Robo expression by Slit, and cytoskeletal remodeling contribute to successful axonal navigation. This article explores the road map and signposts for axon guidance to showcase its importance in neurobiology research.
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Neurobiology I Axon Guidance 20130916
Road map and signposts Axon Guidance Ability of the growing axon to navigate its way through the complex landscape of the developing embryo to its correct target tissue and establish synaptic communication with it. Lowery and Van Vactor, 2009 3
Pioneer axon navigation Bentley and Caudy, 1983
Growing axons are able to recognize various molecules on the surfaces of other axons and cells, and to use these molecules as cues to navigate the sometimes circuitous pathways to their particular destinations. • Also respond to diffusible molecules such as morphogens. • They respond to same cues differently during different developmental stages, thus giving different outputs. Hibbard, 1965
Attraction to midline: due to activation of DCC by netrins. • Crossing and moving from the midline: • Upregulation of Robo expression and repulsion by Slit • Loss of netrin responsiveness even if DCC is expressed.
