Folic Acid and Safety Patrick J. Stover, PhD Cornell University. Biological effects of elevated folate intake (< 1 mg/day) There are no demonstrated toxicities or harmful effects resulting from folate intakes currently achieved by the US population, although
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Patrick J. Stover, PhD
S-adenosylmethionine(vitamin deficiency; SNPs)
(vitamin deficiency; SNPs)
- Cancer- CVD- Demyelination- NTDs
- Cognitive decline
Increased uracil in DNA
Decreased DNA synthesis
Decreased DNA synthesis & reduced cell division
Megaloblastic Anemias – hypersegmented neutrophils
Masking Vitamin B12 deficiency
There is no direct evidence, nor is it known, if folic acid supplements negate the effects of antifolate or antiepileptic drugs (Butterworth & Tamura,1989).