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Imaging Variability in Epilepsy's Language Reorganization

Study on variability in language reorganization in epilepsy patients with MRI scans. Analyzing expected patterns and pathological variations in language areas. Supported by federal grants. Investigating individual vs. group normal maps and patient variance mapping for left partial epilepsy and atypical language. Published in Neurology, 2007.

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Imaging Variability in Epilepsy's Language Reorganization

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  1. Imaging Variability in Disease: Epilepsy & Functional Reorganization of Language William Davis Gaillard Children’s National Medical Center Geo Washington & Georgetown Universities Washington DC Clinical Epilepsy Section, NINDS,NIH Bethesda MD Supported by: Federal Grants R01 NS44280 NINDS, RO1 MH65395 NIMH, P30HD40677 NICHD, U54 MH066417, & Clinical Epilepsy Section NINDS, NIH

  2. Auditory Description Decision Task (ADDT) Group Map: Expected Pattern Individual Maps: Normal & Pathological Variability

  3. Left Partial Epilepsy, MRI, & Atypical Language (n=102) * * * *p<0.05 Gaillard, et al. Neurology 2007

  4. ADDT: Inter & Intra-hemispheric Variance • Individual vs. group normal SPM voxelwise comparison to id voxels with z>2.0 to generate a patient variance map • PCA with hierarchical clustering patient variance maps then grouped into patterns of variance my Kmeans clustering • Data displayed as % (penetrance) for voxels with z>2 for each voxel for each group

  5. ADDT: Inter & Intra-hemispheric Variance • Normal control SPM map (n=19; mean age 24.8) • Patients (n=45; mean age 22.8, onset 13.3), all left hemisphere focus; 73% typical language.

  6. Typical Patient Atypical Patient Individual Patients Compared to Mean Controls

  7. PCA Identifies Four Groups ADDT 1a n=9 1b n=16 2a n=14 n=6 2b 2a&b

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