parental occupation in farming and childhood cancer risk in i4c
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Parental occupation in farming and childhood cancer risk in I4C. Ann Olsson & Joachim Schüz. Rational. Majority of case-control studies show an association Stronger associations with indoor pesticide exposure Internal inconsistencies, e.g. lack of dose-response

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Presentation Transcript
slide2
Rational
  • Majority of case-control studies show an association
  • Stronger associations with indoor pesticide exposure
  • Internal inconsistencies, e.g. lack of dose-response
  • Few cohorts show no or weaker association

Case-control studies are prone to bias!

slide3
Information bias

Recall differences regarding maternaloccupational exposureto pesticides prior to conception

Years between the date of birth and the date of the interview

 cases  controls

[Schüz et al., Am J Epi, 2003]

slide4
Selection bias

Typical pattern:

Social gradient

among controls

[Law, Br J Cancer, 2002]

i4cfarm
I4Cfarm
  • Design: Pool prospective cohorts
  • Benefits:
    • Data collected prior to diagnosis
    • Data collected closer after occurrence
    • Increased power to study “rare events”
slide6
Farming around the world

Proportion of workersemployed in agriculture

Global pesticide production

i4cfarm objectives
I4Cfarm - objectives
  • Investigate if parental occupations in different types of farming is associated with increased risk of cancer in their offspring
  • Evaluate the risk of childhood cancer associated with self reported parental use of pesticides during pregnancy
    • Compare type and frequency reported in case-control studies
  • If possible assess whether the risk of childhood cancer associated with parental exposure to occupation as a farmer and pesticides vary by exposure time-windows (preconception, prenatal, and postnatal)
i4cfarm study team
I4Cfarm – study team
  • IARC (Ann Olsson, Joachim Schüz, Kurt Straif)
  • INSERM (Jacqueline Clavel)
  • MCRI (Gabriella Tikellis)
  • NCI (Martha Linet)
  • CREAL (Martine Vrijheid)
  • Eligible cohorts (PI’s)
    • MoBa, DNBC, ALSPAC, THIS, ?...
next steps
Next steps
  • Eligibility of further cohorts?
  • Transfer of data to MCRI (Gabriella)
  • Harmonization of disease data (Martha) and occupational data (Ann & Martine)
  • Data analyses (at IARC)
  • Manuscripts (Study team)
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