electrical measurement of single molecule catalysis using carbon nanotubes
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Electrical Measurement of Single Molecule Catalysis using Carbon Nanotubes. Brett Goldsmith , Alexander Kane, Vaikunth Khalap , John Coroneus , Gregory Weiss, Phil Collins Department of Physics and Astronomy University of California Irvine. Outline. Single Molecule Sensor Construction

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electrical measurement of single molecule catalysis using carbon nanotubes

Electrical Measurement of Single Molecule Catalysis using Carbon Nanotubes

Brett Goldsmith, Alexander Kane, VaikunthKhalap,

John Coroneus, Gregory Weiss, Phil Collins

Department of Physics and Astronomy

University of California Irvine

outline
Outline
  • Single Molecule Sensor Construction
  • Measurement of Catalysis Reaction Rate
  • Dynamics of the Bound State
single molecule sensors
Single Molecule Sensors

Ensemble

Stochastic

binding analyte absent

binding analyte absent

absent

absent

present

present

device construction
Device Construction

Source

PMMA

PMMA

Drain

Coroneus, et al.Chem. Phys. Chem. accepted

Goldsmith, et al.Science2007, 315, 77.

the catalysis reaction
The Catalysis Reaction

EDC

attached EDC

urea

+

+

EDC binds to the carboxyl group on the nanotube.

The bound EDC perturbs the current in the nanotube.

A reaction with water releases the bound EDC as a mixed urea.

interaction with edc
Interaction With EDC

Goldsmith et al.Nano Lett.,8 (1), 189 -194, 2008

interaction with edc1
Interaction With EDC

Turnover Time

Time Bonded

Waiting Time

single molecule rate constant
Single Molecule Rate Constant

Turnover Time

Time Bonded

Waiting Time

k-1= 58.9 ± 18.3 s

bound state lifetime
Bound State Lifetime

Bound State Lifetime:

= 12.4 ± 2.1 s

k-1= 58.9 ± 18.3 s

energy of a two level system
Energy of a Two Level System

DE = kBTln(/)

~11% of these states are

very different

energy of a two level system1
Energy of a Two Level System

90%

10%

at experimental pH = 4.5

summary
Summary

Goldsmith, et al.Science2007, 315, 77.

Goldsmith et al.Nano Lett.,8 (1), 189 -194, 2008

Goldsmith et al.JMR, accepted

Coroneus, et al.Chem. Phys. Lett., accepted

Dr. Phil Collins

Brett Goldsmith

Alex Kane

Bucky Khalap

Steve Hunt

Danny Wan

Tatyana Sheps

Dr. Gregory Weiss

John Coroneus

ACS-PRF

other samples
Other Samples…

EDC

Pthalic Anhydride

JMR…

amplitude of the two level system
Amplitude of the Two Level System

The amplitude of the two groups of bound states also differs.

These different bound state properties could be due to the ~10% protonated EDC in solution at our conditions.

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