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Regulation of Thrombus Growth: Lagrangian Model and Simulation Approaches

This project proposal by Alexey Tokarev focuses on the regulation of thrombus growth using innovative modeling techniques. It involves the establishment of a Lagrangian model to explore blood flow dynamics, supported by previous works such as Falati et al. (2002) and Tosenberger et al. (2012). The methodology includes reproducing published model results, conducting ODE and stochastic simulations, and deriving dose-response curves for subsystems. We aim to import and debug XML files using SBtb toolbox in MATLAB, enhancing the understanding of platelet activation and thrombus formation through quantitative analysis.

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Regulation of Thrombus Growth: Lagrangian Model and Simulation Approaches

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  1. Project proposal Alexey Tokarev

  2. Regulation of plug/ thrombus growth • Experiment Blood flow Falati et al (2002) fibrin platelets platelets+fibrin • Lagrangian model Tosenberger et al. 2012. Rus. J Num. Anal. Math. Model.

  3. Ca2+ transient oscillations Mazzucato et al., 2002

  4. Platelet activation through Gq GPCRStep 1. Reproduce published model results Purvis, Blood, 2008

  5. ODE simulation

  6. Stochastic simulations

  7. Step 2. Find a dose-response curve (rule) for every subsystem to build a reduced model

  8. Plan / progress • Got xml file from the author • Import into SBtollbox in Matlab (install SBtbx and libSBML) • Fix bugs • Export as correct xml into VCell • ODE formulation • Stochastic formulation • Separate inspection of building blocks

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