Tissue Viability Imager – TiVi600
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Tissue Viability Imager – TiVi600. The non-invasive technology that can ”see through” the top layer of the skin and collect information about the status of the underlying tissue. Skin testing. Drug development. Development of skin care products and cosmetics Microvascular research.

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Tissue Viability Imager – TiVi600

The non-invasive technology that can ”see through” the top layer of the skin and collect information about the status of the underlying tissue.


Skin testing

Drug development

Development of skin care products and cosmetics

Microvascular research

Applications


flash

detector

polarization photo

filter

secondfilter

blocks

polarized light

green plane

red plane

polarized

light

depola-rized

light

algorithm

skin

tissue viability image

Principle

Polarization

Spectroscopy

red light is moderately absorbed by

RBCs

green light is highly absorbed by RBCs


A transparent tubing system filled with RBCs of different concentration is used for modelling the skin microcirculation.

Simulated and measured TiVi-index versus RBC fraction

A linear relationship is

attained between RBC concentration and TiVi output signal.

Validation

Digital camera


User Interface concentration is used for modelling the skin microcirculation.


Features concentration is used for modelling the skin microcirculation.

Small and portable design.

12 images per minute.

2D color presentation.

Video-clip presentation.

Basic data availability.

Benefits

Non-invasive and remote operation.

Instantaneous image capturing.

Not sensitive to movements or ambient light.

User friendly.

Does not influnce the microcirculation.

Calibration not necessary.


Before application of concentration is used for modelling the skin microcirculation.

methyl nicotinate.

About ten minutes

following application of

methyl nicotinate.

Select regions of interest.

Display the Erythema

intensity versus

time curves.

Analysis of time series

Build a video out

of 100 images.


Select a cross-section. concentration is used for modelling the skin microcirculation.

Display the TiVi values along the cross-section versus time.

Analysis of time series


Apply topically: concentration is used for modelling the skin microcirculation.

0.5 mg/ml clobestal proprionate

(20 microliter).

50 mmol methyl nicotinate (20 microliter).

The average TiVi-values for the erythema, blanching and control area.

Erythema and Blanching


Step 1. Drug application by iontophoresis. concentration is used for modelling the skin microcirculation.

Step 2. Capture a sequence of images through the ring-shape iontophoresis electrode and watch the result.

Step 3. Display the time-sequence of average TiVi-values.

Step 4. Generate a dose-response curve.

Transcutaneous drug delivery


Comparison: concentration is used for modelling the skin microcirculation.

Tissue Viability Imaging Laser Doppler Perfusion Imaging

TiVi Quantity LDPI

RBC conc Measurand RBC vel * conc

none Movement artifact sensitivity high

up to 9.000.000 No. ofmeasurement points up to 65.000

low Ambient light sensitivity high

instantaneous Image capturing time minutes

good Portability poor


Thank You! concentration is used for modelling the skin microcirculation.

more info: www.wheelsbridge.se


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