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Tissue Biorepositories: Do You Really Want to Know How the Sausage is Made?. David A. August Professor of Surgery The Cancer Institute of New Jersey UMDNJ / Robert Wood Johnson Medical School. The Cancer Institute of New Jersey. CINJ “SNP” Protocol.

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tissue biorepositories do you really want to know how the sausage is made
Tissue Biorepositories: Do You Really Want to Know How the Sausage is Made?
  • David A. August
  • Professor of Surgery
  • The Cancer Institute of New Jersey
  • UMDNJ / Robert Wood Johnson Medical School

The Cancer

Institute of

New Jersey

cinj snp protocol
CINJ “SNP” Protocol
  • Goal:to identify genetic variants as markers for
    • risk of developing breast cancer
    • earlier age of diagnosis
    • outcomes
  • 1168 patients consented
  • 980 genomic DNAs isolated
  • Demographics to date from chart review
  • Collaborative studies with:
    • Dr. Arnold J. Levine
    • Dr. Vassiliki Karantza-Wadsworth
    • Dr. Shridar Ganesan
    • Dr. Bruce Haffty
    • Dr. Mark Brenneman
types of tissue support

Clinical

Basic

Types of Tissue Support
  • Tissue banking (de- identified:discarded, annotated)
  • Protocol specific support
  • Translational research
  • Bench support
front end back end
Front End / Back End
  • Clinical Processes (collectors)
  • Protocol development
  • Regulatory approval
  • Subject consent
  • Tissue acquisition
  • Clinical analyses
  • Initial processing
  • Clinical annotation
  • Linkage/de-identification
  • Tissue storage
  • Acquisition QA
  • Longitudinal annotation
  • Technical Processes (repository, recipients)
  • Tissue storage
  • Quality assurance
  • Sample preparation
  • Sample distribution
  • Database management
  • End user support
clinical uses
Clinical Uses
  • Prognosis
  • Risk assessment
  • Pharmacodynamics (Phase O trials)
  • “Fingerprinting”
  • Inheritance analysis
  • Etiology
  • Response assessment
  • Response prediction
the worker bees
The Worker Bees
  • Director
  • Pathologist
  • Database development/management/support
  • Manager
  • Technicians (histo, retrieval, IHC, TMA)
  • Data managers, research nurses, chart abstracters
  • Regulatory manager
  • Protocol support (writer, “shepherd”, consultant)
  • Consent docents