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NIH Blueprint: Advancing Neuroscience Research

This framework aims to accelerate progress in neuroscience, optimize research funding, and coordinate activities for understanding brain disorders impacting millions of Americans. Initiatives include gene mapping, neurodevelopment studies, and the Human Connectome Project.

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NIH Blueprint: Advancing Neuroscience Research

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  1. A Framework for Communicating, Collaborating, and Coordinating Michael HuertaCo-Chair, NIH Blueprint Coordinating CommitteeAssociate Director, NIMH

  2. Nervous System Disorders • Account for 6 of the top 10 causes of death* • Affect 1 in 3 Americans • Cost over $500 billion per year** • Major impact on: • academic performance • workplace productivity • social functioning • quality of life Sources: *CDC; **SfN Fact Page

  3. Urgent need to: • Accelerate progress in neuroscience • Maximize bang for the research buck

  4. NIH Blueprint for Neuroscience Research • 16 Institutes, Centers, Offices (ICOs) • Focus on cross-cutting activities • Communicate and adopt best practices • Coordinate the planning & funding of: • Research and development of tools • Education, training, & career development • Research resources • $26 million from ICOs (0.6 % neuroscience) • $12 million from NIH Office of the Director

  5. Neuroscience BlueprintParticipating ICOs NCCAM NIDCD NCRR NICHD NEI NIDCR NIA NIGMS NIAAA NIMH NIBIB NINDS NIDA NINR NIEHS OBSSR

  6. Fiscal Year 2005 Initiatives • GENSAT (gene expression map) Expansion • Microarray Consortium Expansion • Pediatric MRI of Normal Development Expansion • Neurobiology of Disease Curriculum Development • International Neuroinformatics Coordinating Facility • Neuroscience Information Framework

  7. Fiscal Year 2006 Initiatives • Neuromouse – repatriate, develop, and validate driver mouse lines for important genes • Institutional Training Initiatives • Neuroimaging – Physics to Physiology • Computational neuroscience • Neurobiology of disease • Interdisciplinary Core Facility Centers • Neuroimaging Tools and Resources • Clearinghouse for informatics (NITRC) • Imaging activation in ms & mm resolution • Neuroepidemiology Instrument

  8. FY 2007: Neurodegeneration • Biomarkers Research • Therapeutics Delivery Strategies • Interdisciplinary Career Development • Interdisciplinary Postdoctoral Training Human retinal degeneration

  9. FY 2008: Neurodevelopment • Monoclonal Antibodies • Tools for Marking Neural Circuits • Gene Expression Map of the Primate Brain Normal Brain Development, Age 5- 20

  10. FY 2009: Neuroplasticity • Probes and instrumentation for monitoring and manipulating neuroplasticity

  11. FY 2010: Blueprint Grand Challenges

  12. Blueprint Grand Challenge: The Human Connectome Project • Purpose -To develop and share knowledge about the structural and functional connectivity of the healthy, adult human brain • Goals - To have delivered at the end of five years: • Optimized non-invasive imaging tools and methodsto collect human connectivity data, in vivo • High-quality, well-characterized, multi-modal, quantitative datasetsof human connectivity linked to genetic & behavioral data from hundreds of subjects • Dissemination of data, models, and tools to the research community via outreach activities and an informatics platform

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