JEOPARDY

1. JEOPARDY VIROLOGY WEILL CORNELL MEDICAL COLLEGE - QATAR

2. This nucleic acid amplification test for HIV RNA monitors a patient's progress during triple drug therapy and determines the chances of progression to AIDS. What is HIV RT PCR? WEILL CORNELL MEDICAL COLLEGE - QATAR

3. This virus causes an acute febrile rash and produces disease in immunocompetent children. Additionally, in persons with hereditary hemolytic anemia, this virus has been associated with transient aplastic crisis. What is Parvovirus? OR What is Parvovirus B19? WEILL CORNELL MEDICAL COLLEGE - QATAR

4. The initial infection by this virus is often in apparent and occurs through a break in the skin or mucous membranes. Despite high antibody titers, latent infection often persists at the initial site. Temperature change, emotional distress, and hormonal factors often trigger recurrent disease. What is Herpes simplex virus? OR What is HSV? WEILL CORNELL MEDICAL COLLEGE - QATAR

5. An HIV positive patient has a CD4 lymphocyte count and an HIV RNA viral load test done. The following are the results:CD4: 50 CD4 lymphocytes per ulHIV RNA: 750,000 copies per mlThese three drugs are prescribed for the patient. What are azidothymidine (OR AZT), dideoxyinosine (OR DDI) and protease inhibitors? WEILL CORNELL MEDICAL COLLEGE - QATAR

6. Use of the above three drugs inhibits these two viral processes. What are reverse transcriptase (OR RT) and protease? WEILL CORNELL MEDICAL COLLEGE - QATAR

7. The low CD4 count indicates an increased risk for this opportunistic infection, which has been linked to Herpes 8 virus. What is Kaposi's sarcoma? WEILL CORNELL MEDICAL COLLEGE - QATAR

8. Most common in teenagers, this virus, which has symptoms of fever and pharyngitis, is linked to the Epstein-Barr virus. What is infectious mononucleosis (OR mononucleosis OR mono)? WEILL CORNELL MEDICAL COLLEGE - QATAR

9. Rubella infected cells challenged with this family of virus are resistant to subsequent infection and do not exhibit cytopathic effects. What is a picornavirus? WEILL CORNELL MEDICAL COLLEGE - QATAR

10. This protein is produced by cells in response to a viral infection or certain other agents. Its action relates to the synthesis of a protein that inhibits translation or transcription and consequently produces resistance to viral infection. What is interferon? WEILL CORNELL MEDICAL COLLEGE - QATAR

11. These viruses are transmitted by arthropod vectors. What is an arbovirus? WEILL CORNELL MEDICAL COLLEGE - QATAR

12. Patients with either acute or chronic HBV are the only ones who can be infected with this virus. What is HDV (OR Hepatitis D Virus OR Delta Hepatitis)? WEILL CORNELL MEDICAL COLLEGE - QATAR

13. At the ER, an infant presented with a fever and a persistent cough. Physical examination and a chest X-ray suggested pneumonia. This virus is the most likely cause of this infection. What is respiratory syncytial virus (OR RSV)? WEILL CORNELL MEDICAL COLLEGE - QATAR

14. A purine nucleoside analog, this antiviral agent has shown promise with this infant's disease. What is ribavirin (OR What is aerosolized ribavirin)? WEILL CORNELL MEDICAL COLLEGE - QATAR

15. Ranging in size from 24 to 30 nm in diameter, this family of RNA viruses infect the human intestinal tract. Additionally, this family can cause aseptic meningitis, febrile illnesses, and the common cold. What are echoviruses? WEILL CORNELL MEDICAL COLLEGE - QATAR

16. This is the treatment for HSV meningitis or encephalitis. What is acyclovir? WEILL CORNELL MEDICAL COLLEGE - QATAR

17. These two viruses cause a contagious ocular infection characterized by pain, subconjunctival hemorrhages, and swelling of the eyelids, known as acute hemorrhagic conjunctivitis. What are enterovirus and coxsackievirus A (OR coxasckie A virus)? WEILL CORNELL MEDICAL COLLEGE - QATAR

18. A 3-year-old child presents with symptoms of coryza, conjunctivitis, low-grade fever, and Koplik's spots. The causative agent of this disease belongs to this group of viruses. What is paramyxovirus? WEILL CORNELL MEDICAL COLLEGE - QATAR

19. This virus is the cause of one of the most common sexually transmitted diseases, and some serotypes of the virus are linked to cervical carcinoma. What is Human papilloma virus (OR HPV)? WEILL CORNELL MEDICAL COLLEGE - QATAR

20. These RNA viruses are important causes of respiratory diseases in infants and young children, and the diseases caused ranges from a mild febrile cold to bronchiolitis and pneumonia. Additionally, it is the leading cause of the croup syndrome in young children. What is parainfluenza? WEILL CORNELL MEDICAL COLLEGE - QATAR

21. Eastern equine encephalitis could be controlled be eradicating this carrier. What are mosquitoes? WEILL CORNELL MEDICAL COLLEGE - QATAR

22. Children who have had varicella occasionally suffer shingles, a recurrent form of the disease, as adults. The agent causing this disease is a member of this viral family. What is Herpesvirus? WEILL CORNELL MEDICAL COLLEGE - QATAR

23. This is the major cause of the common cold. What is Rhinovirus? WEILL CORNELL MEDICAL COLLEGE - QATAR

24. This acute, febrile illness is characterized by a rash and suboccipital lymphadenopathy. What is German measles? OR What is rubella? WEILL CORNELL MEDICAL COLLEGE - QATAR

25. Finding Negri bodies (cytoplasmic inclusions in the nerve cells of the spinal cord and brain, especially in the hippocampus) in humans is the definitive diagnosis of this disease. What is rabies? WEILL CORNELL MEDICAL COLLEGE - QATAR

26. These cause Creutzfeldt-Jakob Disease. What are prions? WEILL CORNELL MEDICAL COLLEGE - QATAR

27. These are unconventional, self-replicating proteins. What are prions? WEILL CORNELL MEDICAL COLLEGE - QATAR

28. This disease caused by variola virus was eradicated by an intensive vaccination program. What is smallpox? WEILL CORNELL MEDICAL COLLEGE - QATAR

29. This is a defective virus with an RNA genome and a Hepatitis B surface antigen envelope. What is Hepatitis D virus (OR HDV OR Hepatitis Delta Virus)? WEILL CORNELL MEDICAL COLLEGE - QATAR

30. If an individual with Hepatitis B surface antigen is infective and has active hepatitis, he/she would have this antigen as well. What is e antigen? WEILL CORNELL MEDICAL COLLEGE - QATAR

31. Western equine encephalitis is caused by this virus. What is alphavirus? WEILL CORNELL MEDICAL COLLEGE - QATAR

32. Yellow fever and dengue are caused by this virus. What is flavivirus? WEILL CORNELL MEDICAL COLLEGE - QATAR

33. This compound, a synthetic nucleoside structure related to guanosine, has been used successfully against Lassa fever. What is ribavirin? WEILL CORNELL MEDICAL COLLEGE - QATAR

34. An immunocompromised person with a history of seizures had an MRI that revealed a temporal lobe lesion. Multinucleated giant cells with intranuclear inclusions were visible on a brain biopsy. This virus is the most probable cause of the lesion. What is Herpes simplex virus (OR HSV)? WEILL CORNELL MEDICAL COLLEGE - QATAR

35. Foreign service employees who are hospitalized for bleeding ulcers in Zaire are at increased risk for this infection. What is HIV (OR Human Immunodifficiency virus)? WEILL CORNELL MEDICAL COLLEGE - QATAR

36. After a pregnant woman was exposed to rubella, a rubella antibody titer is performed to determine her immune status. This titer ratio is considered protective. What is 1:10? WEILL CORNELL MEDICAL COLLEGE - QATAR

37. This entity is protein material without nucleic acid. While related to a virus, it is a proteinaceous infectious particle that replicates within cells. What is a prion? WEILL CORNELL MEDICAL COLLEGE - QATAR

38. Although a patient has all the gastrointestinal symptoms of HAV, all the tests for HAV-IgG and HAV-IgM are nonreactive. This hepatitis virus is the possible cause of the infection. What is Hepatitis E (OR E)? WEILL CORNELL MEDICAL COLLEGE - QATAR

39. This is the most common cause of postinfluenzal secondary bacterial pneumonia. What is staphylococcus aureus? WEILL CORNELL MEDICAL COLLEGE - QATAR

40. These entities spread St. Louis encephalitis virus and dengue. What are mosquitoes? WEILL CORNELL MEDICAL COLLEGE - QATAR

41. Fever and jaundice characterize this life-threatening disease. Following fever, headache, myalgias, and photophobia, the symptoms progress to the liver, kidney and heart. What is yellow fever? WEILL CORNELL MEDICAL COLLEGE - QATAR

42. Infection by this emerging pathogen, which is endemic in deer mice, can result in influenza-like symptoms followed rapidly by acute respiratory failure. What is hantavirus? WEILL CORNELL MEDICAL COLLEGE - QATAR

43. This virus causes erythema infectiosum (Fifth disease). What is Parvovirus B19? WEILL CORNELL MEDICAL COLLEGE - QATAR

44. This human virus has been implicated in several malignancies including Burkitt's lymphoma, nasopharyngeal carcinoma and some B-cell lymphomas. It is a member of this virus family. What Herpesviruses? WEILL CORNELL MEDICAL COLLEGE - QATAR

45. Epidemic acute respiratory disease, gastroenteritis, whooping cough-like disease, and keratoconjunctivitis are caused by these viruses. What are adenoviruses? WEILL CORNELL MEDICAL COLLEGE - QATAR

46. This is licensed for the treatment of CMV retinitis in AIDS patients. What is ganciclovir? WEILL CORNELL MEDICAL COLLEGE - QATAR

47. These non-lipid containing RNA viruses with a double-shelled capsid are the cause of 30 to 40 percent of acute diarrhea in infants. What are rotaviruses? WEILL CORNELL MEDICAL COLLEGE - QATAR

48. Subacute sclerosing panencephalitis (SSPE) is a progressive encephalitis involving both white and gray matter. It is a late and rare manifestation occurring in 1 of 300,000 cases of this other disease. What is measles? WEILL CORNELL MEDICAL COLLEGE - QATAR

49. Mumps, measles, croup, and bronchiolitis are viral infections associated with this family. What are paramyxoviruses? WEILL CORNELL MEDICAL COLLEGE - QATAR

50. This virus infects the skin or mucosa, causing benign tumors that may undergo malignant conversion and become squamous cell carcinomas. What is papillomavirus? WEILL CORNELL MEDICAL COLLEGE - QATAR