management of acne 1 where do we stand n.
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Management of Acne (Part-1)

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  1. Manuscriptedit Management of Acne – 1 where do we stand ? www.manuscriptedit.com

  2. Introduction • Common disease of pilosebaceous unit in adolescent(Physiologic). • Its cause is multi factorial & has pleomorphic clinical presentation. • Different modality of treatment are available, but selection of appropriate method is Vital.

  3. Naturalhistory • Starts at adolescent-resolve by mid-twenties • 83-95% suffers - at about 14-19years of age • 8% late onset acne - 0ver 25years age

  4. Intro Factorsduction • Genetics • Environmental • Sebum- 1.Triglycride is hydrolysed by P.acnes to free fatty acid, 2. increased squalene,& 3.decreased Linoleic acid • P.acnes- lipase, phosphatase & hyaluronate lyase • Ductal keratinocyte- IL-1,IL-1β, TNF

  5. Major pathological events in acne

  6. Special features of pilosebaceous unit • Propionibacterium acnes-unique composition of sebum • Release of IL-1,IL-1β, TNF from ductal keratinocytes • Androgen receptors – Keratinocytes of hair follicle & Basal cells of sebaceous unit • Follicular keratinocytes has – increased 17β-hydroxysteroid dehydrogenase &5-reductase activity (Type-I isoenzyme)[pivotal in development of sebaceous gland and acne]

  7. Factors responsible for Keratinocyte hyperproliferation • Androgenic hormone Dihydrotestosterone (DHT) • Decrease Linoleic acid • Increased Interleukin (IL)-1 

  8. Management of Acne Part – 2 (Coming Soon) THANK YOU

  9. VISIT www.manuscriptedit.com