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Attenuation of Fas Ligand-Induced Hyperpermeability in RLMECs by Recombinant FasFc

This study investigates how recombinant human FasFc chimeric protein reduces Fas ligand-induced hyperpermeability in RLMECs. Results show a significant decrease in cell permeability when treated with FasFc compared to Fas ligand alone. FasFc treatment alone did not alter permeability.

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Attenuation of Fas Ligand-Induced Hyperpermeability in RLMECs by Recombinant FasFc

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  1. Supplemental Digital Content: S2 * a Fluorescent Intensity (% Control) Control Fas Ligand FasFc + Fas Ligand FasFc Recombinant human FasFc chimeric protein attenuates Fas ligand induced hyperpermeability in RLMECs. Fas Ligand increases RLMEC permeability compared to untreated control cells (*p < 0.05; n = 6). Fas ligand treated monolayers when pre-treated with FasFc show significant decrease in permeability compared with Fas ligand treated monolayers (a p < 0.05; n = 6). FasFc alone treated group shows no significant change in permeability compared to the untreated control cells.

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