METHACHOLINE AND ADENOSINE 5’-MONOPHOSPHATE CHALLENGES IN PRESCHOOL CHILDREN WITH COUGH-VARIANT AND CLASSIC ASTHMA Gazi University Faculty of Medicine Department of Pediatric Allergy and Asthma
PC20Adenosine: related with airway inflammation in asthma More sensitive than methacholine in monitoring response to asthma treatment PC20Methacholine: related with structural changes in asthma JACI 2006;118(3): 551 ADENOSINE 5’-MONOPHOSPHATE (AMP) • Effector cell: mast cell • Indirect bronchoconstrictor
BACKGROUND • In school children and adults CVA is not different from • classic asthma concerning the methacholine responsiveness, airway inflammation and remodelling • No study has compared AMP responsiveness between • CVA and classic asthma in any age group
AIM Bronchial challenge with different stimuli provides different information and may be used as an adjunct to understand the pathophysiology of cough variant asthma (CVA) in young children in whom the mechanism of disease is still unresolved.
METHACHOLINE PC15PtcO2Methacholine (mg/ml) Cough Variant asthma Calssic asthma Control
AMP PC15PtcO2AMP (mg/ml) Cough Variant asthma Calssic asthma Control
CONCLUSION Pre-school children with CVA were found to differ from children with classic persistent asthma with regard to response profiles to AMP challenge which may point to different pathophysiologic mechanisms of CVA in the young age group. Ped Pulmonol 2007; 42: 973