Comparative Analysis of Gene Expression Profiles in Primary Patient Tumors and PDTX Tumors

Jul 07, 2025

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This study by Tentler et al. (2012) compares genome-wide gene expression profiles between primary patient tumors and patient-derived tumor xenograft (PDTX) tumors. The research explores PDTX tumors as models for oncology drug development.

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gene expression
patient tumors
pdtx tumors
oncology drug development
comparative analysis

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Comparative Analysis of Gene Expression Profiles in Primary Patient Tumors and PDTX Tumors

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Figure 2Comparison of genome-wide gene-expression profiles between primary patient tumours and PDTX tumours Tentler, J. J. et al.(2012) Patient-derived tumour xenografts as models for oncology drug development Nat. Rev. Clin. Oncol. doi:10.1038/nrclinonc.2012.61

nrneph.2012.214-pf2

Figure 2 Recovery of renal function is better with a shorter interval between onset of aHUS and initiation of eculizumab. Zuber, J. et al. (2012) Use of eculizumab for atypical haemolytic uraemic syndrome and C3 glomerulopathies Nat. Rev. Nephrol. doi:10.1038/nrneph.2012.214.

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Figure 1 Comparison of a | PFS and b | overall survival curves from the JGOG study on dosedense therapy 1 and the GOG study on IP therapy. Thomas Hogberg (2010) Current drugs still have potential in advanced ovarian cancer Nat. Rev. Clin. Oncol. doi:10.1038/nrclinonc.2010.37.

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Figure 2 Genotype frequencies for rs17817964 within and across ancestries based on the 1000 Genomes Project. Loos, R. J. F. & Yeo, G. S. H. (2013) The bigger picture of FTO —the first GWAS‑identified obesity gene Nat. Rev. Endocrinol. doi:10.1038/nrendo.2013.227.

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Figure 2 Schematic representation of potential depot-specific differences between subcutaneous and visceral adipose tissue in mice with normal GH signalling, low GH signalling (such as Ghr –/– mice) or increased GH signalling (such as GH transgenic mice).

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Figure 2 The role of TEE in determining suitability of mechanical LAA occlusion and in guiding device sizing. Yu, C.‑M. et al. (2013) Mechanical antithrombotic intervention by LAA occlusion in atrial fibrillation Nat. Rev. Cardiol. doi:10.1038/nrcardio.2013.158.

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Figure 2 Examples of whole body scans and whole body radioiodine retention either after administration of rhTSH or after THW.

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Figure 2 MRI scan obtained 2 weeks after admission and 1 week after initiation of corticosteroid therapy. Plotkin, SR et al. (2005) Facial numbness in a man with inguinal and retroperitoneal masses . Nat Clin Pract Oncol 2 : 54 – 58 10.1038/ncponc0059.

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Figure 2 Polysomnography (hypnogram) coupled with penile tumescence recordings demonstrate three episodes of rapid eye movement sleep-related erection with pain and awakening. Karsenty G et al . (2005) Sleep-related painful erections Nat Clin Pract Urol 2: 256 –260 doi:10.1038/ ncpuro0184.

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Figure 2 A brain biopsy specimen stained with hemotoxylin and eosin showed foci of microglia and lymphocytes involving the leptomeninges and neuropil. Valcour V et al . (2008) A case of enteroviral meningoencephalitis presenting as rapidly progressive dementia

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Figure 2 Factors influencing differential diagnoses of drug-related hepatitis in individuals with elevated levels of aspartate aminotransferase, alanine aminotransferase,  -glutamyltransferase, alkaline phosphatase and bilirubin (both conjugated and unconjugated).

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Figure 2 Kaplan–Meier curves from a Norwegian population-based study showing influence of MH on outcomes in patients with IBD.

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Figure 2 The proteins involved in the RB1 and p53 pathways with some interactions with the P13K/PKB pathway. Collins VP (2007) Mechanisms of Disease: genetic predictors of response to treatment in brain tumors Nat Clin Pract Oncol 4 : 362 –374 doi:10.1038/ncponc0820.

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Figure 2 Suggested algorithm for assessment, monitoring and management of patients with RA‑ILD on biologic therapy. Jani, M. et al. (2013) The safety of biologic therapies in RA‑associated interstitial lung disease Nat. Rev. Rheumatol. doi:10.1038/nrrheum.2013.197.

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Garneau et al. Nature Reviews Molecular Cell Biology 8 , 113 – 126 (February 2007) | doi:10.1038/nrm2104.

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Thiery et al. Nature Reviews Molecular Cell Biology 7 , 131 – 142 (February 2006) | doi:10.1038/nrm1835.

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Figure 2 A CT scan of a patient with a massive pseudocyst of the pancreas that compressed not only the stomach but also the duodenum. O'Keefe SJD (2009) A guide to enteral access procedures and enteral nutrition Nat Rev Gastroenterol Hepatol doi:10.1038/nrgastro.2009.20.

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Figure 1 Forrest plot showing pooled data for a | incidence of clinical fractures and b | incidence of breast cancer recurrence from the Z‑FAST, ZO‑FAST and EZO‑FAST studies.

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Figure 2 Spatial patterns of task-free networks commonly investigated in neurodegenerative disorders. Pievani, M. et al. (2014) Brain connectivity in neurodegenerative diseases—from phenotype to proteinopathy Nat. Rev. Neurol. doi:10.1038/nrneurol.2014.178.

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Figure 2 Transversal CT image of a typical small-bowel neuroendocrine tumour mesenteric metastasis (arrow). van Essen, M. et al. (2013) Neuroendocrine tumours: the role of imaging for diagnosis and therapy Nat. Rev. Endocrinol. doi:10.1038/nrendo.2013.246.

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Figure 2 The aldosterone paradox. Aldosterone exerts differential effects during hypovolaemia and hyperkalaemia. Sevá Pessôa, B. et al . (2012) Key developments in renin–angiotensin–aldosterone system inhibition Nat. Rev. Nephrol. doi:10.1038/nrneph.2012.249.

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Figure 2 Activation of C3 convertase is involved in both complement-mediated and immune-complex-mediated MPGN. Bomback, A. S. & Appel, G. B. (2012) Pathogenesis of the C3 glomerulopathies and reclassification of MPGN Nat. Rev. Nephrol. doi:10.1038/nrneph.2012.213.

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Figure 2 Periodic discharges of nonconvulsive status epilepticus following convulsive status epilepticus. Korff CM and Nordli DR (2007) Diagnosis and management of nonconvulsive status epilepticus in children Nat Clin Pract Neurol 3: 505 –516 10.1038/ncpneuro0605.

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