Genetic Predictors of Brain Tumor Treatment Response: Pathways and Interactions

Mar 04, 2025

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This study explores the proteins involved in the RB1 and p53 pathways and their interactions with the PI3K/PKB pathway, shedding light on genetic predictors of response to treatment in brain tumors.

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Genetic Predictors of Brain Tumor Treatment Response: Pathways and Interactions

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Figure 2 The proteins involved in the RB1 and p53 pathways with some interactions with the P13K/PKB pathway Collins VP (2007) Mechanisms of Disease: genetic predictors of response to treatment in brain tumorsNat Clin Pract Oncol 4: 362–374 doi:10.1038/ncponc0820

Priority School Building Programme – PF2 Hertfordshire, Luton and Reading Batch

Priority School Building Programme – PF2 Hertfordshire, Luton and Reading Batch. DfE Final FBC Approval Point. Post preferred bidder - design development, financing, planning. DfE developing SOC. Pre close of dialogue draft final bids submitted. EFA developing OBC. DfE SOC Approval Point.

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nrclinonc.2012.61-pf2

Figure 2 Comparison of genome-wide gene-expression profiles between primary patient tumours and PDTX tumours. Tentler, J. J. et al. ( 2012) Patient-derived tumour xenografts as models for oncology drug development Nat. Rev. Clin. Oncol. doi:10.1038/nrclinonc.2012.61.

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nrneph.2012.214-pf2

Figure 2 Recovery of renal function is better with a shorter interval between onset of aHUS and initiation of eculizumab. Zuber, J. et al. (2012) Use of eculizumab for atypical haemolytic uraemic syndrome and C3 glomerulopathies Nat. Rev. Nephrol. doi:10.1038/nrneph.2012.214.

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nrendo.2013.227-pf2

Figure 2 Genotype frequencies for rs17817964 within and across ancestries based on the 1000 Genomes Project. Loos, R. J. F. & Yeo, G. S. H. (2013) The bigger picture of FTO —the first GWAS‑identified obesity gene Nat. Rev. Endocrinol. doi:10.1038/nrendo.2013.227.

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nrendo.2013.64-pf2

Figure 2 Schematic representation of potential depot-specific differences between subcutaneous and visceral adipose tissue in mice with normal GH signalling, low GH signalling (such as Ghr –/– mice) or increased GH signalling (such as GH transgenic mice).

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nrcardio.2013.158-pf2

Figure 2 The role of TEE in determining suitability of mechanical LAA occlusion and in guiding device sizing. Yu, C.‑M. et al. (2013) Mechanical antithrombotic intervention by LAA occlusion in atrial fibrillation Nat. Rev. Cardiol. doi:10.1038/nrcardio.2013.158.

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Figure 2 Examples of whole body scans and whole body radioiodine retention either after administration of rhTSH or after THW.

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ncponc0059-pf2

Figure 2 MRI scan obtained 2 weeks after admission and 1 week after initiation of corticosteroid therapy. Plotkin, SR et al. (2005) Facial numbness in a man with inguinal and retroperitoneal masses . Nat Clin Pract Oncol 2 : 54 – 58 10.1038/ncponc0059.

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ncpuro0184-pf2

Figure 2 Polysomnography (hypnogram) coupled with penile tumescence recordings demonstrate three episodes of rapid eye movement sleep-related erection with pain and awakening. Karsenty G et al . (2005) Sleep-related painful erections Nat Clin Pract Urol 2: 256 –260 doi:10.1038/ ncpuro0184.

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ncpneuro0804-pf2

Figure 2 A brain biopsy specimen stained with hemotoxylin and eosin showed foci of microglia and lymphocytes involving the leptomeninges and neuropil. Valcour V et al . (2008) A case of enteroviral meningoencephalitis presenting as rapidly progressive dementia

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ncpgasthep0871-pf2

Figure 2 Factors influencing differential diagnoses of drug-related hepatitis in individuals with elevated levels of aspartate aminotransferase, alanine aminotransferase,  -glutamyltransferase, alkaline phosphatase and bilirubin (both conjugated and unconjugated).

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nrgastro.2009.203-pf2

Figure 2 Kaplan–Meier curves from a Norwegian population-based study showing influence of MH on outcomes in patients with IBD.

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nrrheum.2013.197-pf2

Figure 2 Suggested algorithm for assessment, monitoring and management of patients with RA‑ILD on biologic therapy. Jani, M. et al. (2013) The safety of biologic therapies in RA‑associated interstitial lung disease Nat. Rev. Rheumatol. doi:10.1038/nrrheum.2013.197.

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nrm2104-pf2

Garneau et al. Nature Reviews Molecular Cell Biology 8 , 113 – 126 (February 2007) | doi:10.1038/nrm2104.

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nrm1835 pf2

Thiery et al. Nature Reviews Molecular Cell Biology 7 , 131 – 142 (February 2006) | doi:10.1038/nrm1835.

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nrgastro.2009.20 pf2

Figure 2 A CT scan of a patient with a massive pseudocyst of the pancreas that compressed not only the stomach but also the duodenum. O'Keefe SJD (2009) A guide to enteral access procedures and enteral nutrition Nat Rev Gastroenterol Hepatol doi:10.1038/nrgastro.2009.20.

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nrneurol.2014.178 pf2

Figure 2 Spatial patterns of task-free networks commonly investigated in neurodegenerative disorders. Pievani, M. et al. (2014) Brain connectivity in neurodegenerative diseases—from phenotype to proteinopathy Nat. Rev. Neurol. doi:10.1038/nrneurol.2014.178.

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nrendo.2013.246 pf2

Figure 2 Transversal CT image of a typical small-bowel neuroendocrine tumour mesenteric metastasis (arrow). van Essen, M. et al. (2013) Neuroendocrine tumours: the role of imaging for diagnosis and therapy Nat. Rev. Endocrinol. doi:10.1038/nrendo.2013.246.

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nrneph.2012.249 pf2

Figure 2 The aldosterone paradox. Aldosterone exerts differential effects during hypovolaemia and hyperkalaemia. Sevá Pessôa, B. et al . (2012) Key developments in renin–angiotensin–aldosterone system inhibition Nat. Rev. Nephrol. doi:10.1038/nrneph.2012.249.

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nrneph.2012.213 pf2

Figure 2 Activation of C3 convertase is involved in both complement-mediated and immune-complex-mediated MPGN. Bomback, A. S. & Appel, G. B. (2012) Pathogenesis of the C3 glomerulopathies and reclassification of MPGN Nat. Rev. Nephrol. doi:10.1038/nrneph.2012.213.

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ncpneuro0605 pf2

Figure 2 Periodic discharges of nonconvulsive status epilepticus following convulsive status epilepticus. Korff CM and Nordli DR (2007) Diagnosis and management of nonconvulsive status epilepticus in children Nat Clin Pract Neurol 3: 505 –516 10.1038/ncpneuro0605.

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Single Cell RNAseq at PF2

Single Cell RNAseq at PF2. Plate-forme Transcriptome et Epigénome – Biomics – CITECH. Odile Sismeiro and Marie-Agnès Dillies. 22/09/2015. Presentation. Why the Single Cell ?. Standard RNASeq. Single Cell RNASeq. Person of the year 2013 Time Magazine. Uniformity. Specificity.

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