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Evaluation of topical dosage forms

Evaluation of topical dosage forms. DR. J. DOMENECH. Topical delivery includes two basic types of product: 1. External topicals that are spread, sprayed, or otherwise dispersed on to cutaneous tissues to cover the affected area.

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Evaluation of topical dosage forms

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  1. Evaluation of topical dosage forms DR. J. DOMENECH

  2. Topical delivery includes two basic types of product: • 1. External topicals that are spread, sprayed, or otherwise dispersed on to cutaneous tissues to cover the affected area. • 2. Internal topicals that are applied to the mucous membrane orally, vaginally  or on  anorectal tissues for local activity.

  3. Advantages of Topical Drug Delivery Systems • Avoidance of first pass metabolism. • Convenient and easy to apply. • Avoidance of  the risks and inconveniences of intravenous therapy and of the varied conditions of absorption, like pH changes, presence of enzymes, gastric emptying time etc. • Achievement of efficacy with lower total daily dosage of drug by continuous drug input. • Avoids fluctuation in drug levels, inter- and intrapatient variations.

  4. Ability to easily terminate the medications, when needed. • A  relatively large area of application in comparison with buccal or nasal cavity • Ability to deliver drug more selectively to a specific site. • Avoidance of gastro-intestinal incompatibility. • Providing utilization of drugs with short biological half-life, narrow therapeutic window. • Improving physiological and pharmacological response. • Improve patient compliance. • Provide suitability for self-medication.

  5. Disadvantages of Topical Drug Delivery Systems • Skin irritation of contact dermatitis  may  occur  due to the drug and/or excipients. • Poor permeability of some drugs  through  the  skin. • Possibility of allergenic reactions. • Can be used only for drugs which require very small plasma concentration for action • Enzyme in epidermis may denature the drugs • Drugs of larger particle size not easy to absorb through the skin

  6. The layers of skin

  7. The layers of epidermis • Stratum Germinativum (Growing Layer) • Malpighion Layer (pigment Layer) • Stratum Spinosum (Prickly cell Layer) • Stratum Granulosum (Granular Layer) • Stratum Lucidum • Stratum Corneum (Horny Layer)

  8. Evaluation Of Topical Dosage Form

  9. Evaluation Of Topical Dosage Form

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  18. Brookfield viscometer(RVT)

  19. Evaluation Of Topical Dosage Form

  20. Thanks for your attention

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