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Knoll Pharmaceuticals/ BASF Pharma. Valerie Cuba Chem 280 April 3, 2001. History of Knoll AG. Dr. Albert Knoll and Hans Knoll founded Knoll AG in 1886 Develops a cost effective way of producing codeine from morphine In 1893, starts producing theobromine from cocoa bean shells

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knoll pharmaceuticals basf pharma

Knoll Pharmaceuticals/ BASF Pharma

Valerie Cuba

Chem 280

April 3, 2001

history of knoll ag
History of Knoll AG
  • Dr. Albert Knoll and Hans Knoll founded Knoll AG in 1886
  • Develops a cost effective way of producing codeine from morphine
  • In 1893, starts producing theobromine from cocoa bean shells
  • In 1895, developed Tanalbin, an antidiiarrhoeal; further made into Tannacomp, product still sold
history continued
History Continued
  • 1906- Launches Digipuratum
  • 1935- Minden facilities for production site of ephedrine
  • 1963- Launches world’s first calcium channel blocker, Isoptin
  • 1964- BASF AG acquires 15% ownership
  • 1971- Launches Iruxol, promotes wound healing
  • 1985- Knoll AG becomes fully owned by BASF
areas of research development
Areas of Research & Development
  • Obesity
  • Rheumatology
  • Cardiovascular disease
  • Thyroid disease
  • Immunology
ephedrine
Ephedrine
  • Used to treat respiratory tract disease and circulatory disorders
  • Ephedrine synthesis process developed as early as 1930

C10H15NO

isoptin
Isoptin
  • World’s first calcium channel blocker (1963)
  • Active substance: verapamil
  • Treats hypertension
  • Remains one of Knoll’s top selling products today
slide7
Appetite suppresser
  • Active Ingredient: Sibutramine
  • Increases the activity of certain chemicals, norepinephrine and serotonin, in the brain
synthroid
Synthroid
  • Treats Thyroid disease
  • Active Ingredient: levothyroxine sodium
  • Replaces hormone that is usually made by normal thyroid glands
new innovations of knoll
New Innovations of Knoll
  • Reductil, treats obesity
  • Gopten & Tarka, manages hypertension
  • Zoleptil, treats schizophrenia