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Immune System. Objectives To select genes that are embryonic lethal Or accept bone marrow from other centres Generate bone marrow chimeras Or generate conditional mutants for EUCOMM allels Analyse phenotypes of these mutants and Establish the course of embryonic lethality.

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Immune system
Immune System

  • Objectives

    • To select genes that are embryonic lethal

      • Or accept bone marrow from other centres

    • Generate bone marrow chimeras

      • Or generate conditional mutants for EUCOMM allels

    • Analyse phenotypes of these mutants and

      • Establish the course of embryonic lethality


Members of the network
Members of the Network

  • Principal Investigator

  • Werner Muller, University of Manchester, Faculty of Life Science, AV Hill Building, M13 9PT Manchester; Email: [email protected]

  • Co-Investigators

  • Immunology: Richard Grencis, Kathryn Else, Mark Travis, Sheena Cruikshank,Douglas Millar, Dr. Mat Hardman,Paul Lyons, Jim Middleton

  • Immune Toxicology:Ian Kimber

  • Neurobiology: Emmanuel Pinteaux, Stuart Allan

  • Cardiology: Ludwig Neyses, Elizabeth Cartwright, DelvacOceandy

  • Developmental Biology:Mike Dixon, Kathryn Hentges

  • Human Genetics: YanickCrow

  • Bioinformatics: Andy Brass, Robert Stevens

  • Manchester Centre for Nuclear Hormone Research in Disease: David Ray


Example 1
Example 1

Analysis of a B cell phenotype for an embryonic lethal mutation (polymerase beta)


Example 2
Example 2

Analysis of a complex phenotype for an embryonic lethal mutation using conditional gene targeting (gp130)


neurological, cardiac, hematopoietic, immunological, hepatic and pulmonary


neurological, cardiac, hematopoietic, immunological, hepatic and pulmonary


Immune system1
Immune System

  • Objectives

    • To select genes that are embryonic lethal

      • Or accept bone marrow from other centres

    • Generate bone marrow chimeras

      • Or generate conditional mutants for EUCOMM allels

    • Analyse phenotypes of these mutants and

      • Establish the course of embryonic lethality


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