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Systems Engineering Research and the Cancer Care Engineering Project. Joseph F. Pekny, Ph. D. (Purdue University) Professor of Chemical Engineering Interim Head of Industrial Engineering. Cancer Care Engineering. Project Leads: Pat Loehrer, MD Kenneth Wiseman Professor of Medicine

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systems engineering research and the cancer care engineering project

Systems Engineering Research and the Cancer Care Engineering Project

Joseph F. Pekny, Ph. D. (Purdue University)

Professor of Chemical Engineering

Interim Head of Industrial Engineering

cancer care engineering
Cancer Care Engineering

Project Leads:

Pat Loehrer, MD

Kenneth Wiseman Professor of Medicine

Director, IU Simon Cancer Center

Associate Dean of Cancer Research

Indiana University School of Medicine

Joe Pekny, PhD

Professor of Chemical Engineering

Interim Department Chair, Industrial Engineering

Founder, Regenstrief Center for Healthcare Engineering

Purdue University

Marietta Harrison, PhD

Professor of Medicinal Chemistry

Associate Vice President for Research

Director, Oncological Sciences Center

Purdue University

project funding
Project Funding
  • U.S. Army Medical and Materiel Command
    • $2.3M
    • Negotiating additional award
  • Regenstrief Foundation
    • $1.35M
  • Walther Cancer Foundation
    • $1.8M
  • NIH (2) and DoD (1) pending
opportunity further systematizing cancer care innovation
Opportunity: Further Systematizing Cancer Care Innovation

Thousands of Journal Articles, Best Practices, Landmark Studies, Rapid IT Advances, Large Amounts of Data, Systems Biology, Golden Age of Life Science

Breakthrough Cures, Uneven Care, “Miracle” Patients, Policy Needs, Ongoing Opportunity for Reality to Research and Back

Cancer Care Engineering

Science & Technology

Cancer Care Practice

slide6

“We want to know with certainty whether the treatment protocol for a young, non-smoking mother of 3 with colon cancer will work. Today we can only tell her in terms of percentages the potential treatment effectiveness. The monthly cost is in the tens of thousands and may not be effective for her. We order it and hope.”

  • Goal
  • Needs Better Tool Now
  • Needs Way to Rapidly Improve Tools Going Forward by Applying More, Advancing, and Targeting Science and Technology

CCE Summary: Processing Samples, in Position to Develop First Generation Pilot Tools

prevention treatment sample acquisition analysis colorectal cancer patient subgroups
Prevention & Treatment: Sample Acquisition & Analysis (Colorectal Cancer): Patient Subgroups

CCE Component in Progress

personalizing cancer care the importance of patient groups

Clinical Trials

Clinical Trials

Clinical Trials

Clinical Trials

Phase I

Phase I

Phase I

Phase I

Phase II

Phase II

Phase II

Phase II

Phase III

Phase III

Phase III

Phase III

Clinical Trials

Phase I

Phase II

Phase III

Drug X

Personalizing Cancer Care: The Importance of Patient Groups

On which patient groups does Drug X work?

Patient groups are indistinguishable with respect to treatment

What dosage is best?