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MODO ( “ M odels O f D iabetes and O besity”) Consortium

MODO ( “ M odels O f D iabetes and O besity”) Consortium. Toni Vidal- Puig & Tony Coll. Obesity, diabetes and related metabolic diseases are major and increasing threats to public health. <10% 10%–14% 15%–19% 20%–24% 25%–29%

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MODO ( “ M odels O f D iabetes and O besity”) Consortium

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  1. MODO ( “Models Of Diabetes and Obesity”) Consortium Toni Vidal-Puig & Tony Coll

  2. Obesity, diabetes and related metabolic diseases are major and increasing threats to public health <10% 10%–14% 15%–19% 20%–24% 25%–29% ≥30% Obesity 2007 Diabetes 2007

  3. Obesity, diabetes and related metabolic diseases are major and increasing threats to public health <10% 10%–14% 15%–19% 20%–24% 25%–29% ≥30% Obesity 2010 Obesity 2007

  4. Obesity, diabetes and related metabolic diseases are major and increasing threats to public health There remains a major unmet need for therapy and prevention

  5. The MODO Consortium

  6. Dundee Mike Ashford Calum Sutherland Rory McCrimmon Ewan Pearson OCDEM Mark McCarthy Anna Gloyn Patrick Rorsman Frederick Karpe Cecilia Lindgren MRC CORD Toni Vidal Puig Tony Coll + colleagues MRC Epidemiology Nick Wareham Ruth Loos University of Oxford Frances Ashcroft MRC HNR Jules Griffin Imperial Guy Rutter MRC Harwell Roger Cox MRC-CSC Dominic Withers University College, London Rachel Batterham The MODO Consortium

  7. Specific aims • To understand the molecular determinants of nutrient sensing and energy balance. To advance our understanding of B cell function and insulin action. physiology To understand how alterations in theses pathways lead to metabolic disease pathology • To identify and develop specific therapeutic interventions. therapeutics

  8. IMPC programme

  9. transcriptional profiling data from existing models genetic association studies whole exome sequencing IMPC programme

  10. transcriptional profiling data from existing models genetic association studies whole exome sequencing Secondary phenotyping

  11. Murinephenotyping Dundee Cambridge London “Fine grained” , bespoke metabolic phenotyping Energy balance and body composition Whole body glucose homeostasis Histology Environmental influences Diet Activity Temperature Obesity associated metabolic complications

  12. Metabolic disease - a disorder of whole organisms, not simply one system.

  13. Metabolic disease - a disorder of whole organisms, not simply one system. neuroendocrinology brown adipose gut muscle behaviour pancreas liver adipocyte biology

  14. Mechanistic cellular phenotyping - pancreas Ashcroft Rutter Withers Ashford Rorsman Gloyn

  15. Molecular phenotyping Expression profiling Pharmocogenomics Pearson, Sutherland. McCarthy & colleagues Withers, Yeo

  16. Detailed human phenotyping Energy balance Body composition Functional imaging Fatty acid metabolism BatterhamKarpeFarooqi Savage Semple

  17. For discussion • Metabolic phenotypes are not necessarily acute or extreme • – implications for primary screen • Linking in with other programmes involving areas of expertise not historically allied to metabolic disease • Data integration- within the consortium, within the whole IMPC • Quality control during protocols and data acquisition • Funding

  18. Dundee Mike Ashford Calum Sutherland Rory McCrimmon Ewan Pearson OCDEM Mark McCarthy Anna Gloyn Patrick Rorsman Frederick Karpe Cecilia Lindgren MRC CORD Toni Vidal Puig Tony Coll + colleagues MRC Epidemiology Nick Wareham Ruth Loos University of Oxford Frances Ashcroft MRC HNR Jules Griffin Imperial Guy Rutter MRC Harwell Roger Cox MRC-CSC Dominic Withers University College, London Rachel Batterham The MODO Consortium

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