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ELM PHOSPHO.ELM. June 2009 bioinformatics workshop. Irit Kisslov Noam Harif. E ukaryotic L inear M otif. Collection of small functional sites/motives. Examples: - protein interaction sites - cell compartment targeting signals - post-translational modifications sites

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ELM

PHOSPHO.ELM

June 2009 bioinformatics workshop

Irit Kisslov Noam Harif

e ukaryotic l inear m otif
Eukaryotic Linear Motif
  • Collection of small functional sites/motives.
  • Examples:

- protein interaction sites

- cell compartment targeting signals

- post-translational modifications sites

- cleavage sites

functional sites vs globular domains
Functional sites vs. globular domains

Difficult to analyse productively

Why?

There are many of them.

They are short.

No defined structure.

False positive results.

elm aims
ELM aims:
  • Creation of a comprehensive database of eukaryotic linear motifs
  • Providing a resource to aid in ELM discovery
how to improve elm as to be useful prediction tool
How to improve ELM as to be useful prediction tool?

Building algorithm for prediction using ELM database.

Searching for the known motifs in given protein.

Evaluation of the results found by ELM.