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Attenuation of Fas Ligand-Induced Hyperpermeability in RLMECs by Z-DEVD-FMK

This study explores how Z-DEVD-FMK, a Caspase-3 inhibitor, mitigates Fas ligand-induced hyperpermeability in RLMECs. Results show a significant decrease in permeability in treated monolayers compared to controls.

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Attenuation of Fas Ligand-Induced Hyperpermeability in RLMECs by Z-DEVD-FMK

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  1. Supplemental Digital Content: S3 * a Fluorescent Intensity (% Control) Control Fas Ligand Z-DEVD + Fas Ligand Z-DEVD Caspase-3 inhibitor, Z-DEVD-FMK attenuates Fas ligand induced monolayer hyperpermeability in RLMECs. Hyperpermeability in RLMECs is expressed as a percentage of the basal fluorescence. Fas ligand treated monolayers show significant increase in permeability compared to the untreated control monolayers (*p < 0.05; n = 6). Fas ligand treated monolayers when pre-treated with Z-DEVD-FMK show significant decrease in permeability compared to the Fas ligand treated monolayers (a p < 0.05; n = 6). Z-DEVD-FMK alone treated group shows no significant change in permeability compared to the untreated control cells.

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