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Name(s): Peter Hu High School(s): Texas Academy of Mathematics and Science

Name(s): Peter Hu High School(s): Texas Academy of Mathematics and Science Mentor: Dr. Liping Tang Project Title: Novel Thermogelling Dispersions of Polymer Nanoparticles for Controlled Drug Delivery.

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Name(s): Peter Hu High School(s): Texas Academy of Mathematics and Science

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  1. Name(s): Peter Hu High School(s): Texas Academy of Mathematics and Science Mentor: Dr. Liping Tang Project Title:Novel Thermogelling Dispersions of Polymer Nanoparticles for Controlled Drug Delivery The development of delivery systems for therapeutic proteins is critically important for treating various diseases, but a major problem is that there is not a suitable protein drug carrier that can maintain a sustained release while protecting the protein from degradation in the human body. The purpose of this project is to solve this problem by creating a novel, biocompatible thermogelling dispersion of polymer nanoparticles as a protein drug carrier. Nanoparticles were composed of two biocompatible interpenetrating polymer networks (IPN): thermo-sensitive poly(ethylene glycol) derivative (PEGd) polymers and thermo-insensitive poly(acrylic acid) (PAAc). The physical properties of the nanoparticles were characterized using atomic force microscopy and dynamic light scattering. The aqueous dispersion of nanoparticles exhibited a thermogelling effect, characterized by a drastic increase in viscosity, as the temperature increased from 20 to 37 °C. For controlled drug delivery tests, insulin was mixed with the fluid dispersion at room temperature. At 37 °C, the dispersion formed a gel, which produced a release of insulin with an initial burst followed by a sustained release over a long period of time, as verified by protein assay measurements. Such a steady, continuous release demonstrates that this dispersion has potential as a suitable protein drug carrier.

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