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Passende Bildauswahl !

Training. Passende Bildauswahl !. Essential nutrients for your health. good night. What is a Food Supplement?. Content. Key message Introduction Product information Key benefits Target group Posology & administration Ingredients Sleep-Wake-Cycle Insomnia Good to know

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Passende Bildauswahl !

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  1. Training Passende Bildauswahl! Essential nutrients for your health good night

  2. Whatis a Food Supplement?

  3. Content Key message Introduction Product information Key benefits Target group Posology & administration Ingredients Sleep-Wake-Cycle Insomnia Good to know Complementary treatment Train thebrain References

  4. 1. Key message • DID YOU KNOW THAT… ? • … wespendup to onethirdofourlivesasleep? • Sleep is vital andplays an essential rolewithinbiologicaland mental processes. • Sleep deprivationisassociatedwithpsychosocialimpairments like daytimesleepiness, lack ofconcentration, poorhealthordiscomfort. • goodnight Denk supportssleepqualityandthus • improvesqualityoflife. • helps to play an activerole in socialand professional life.

  5. 2. Introduction • 30 % of the general population has complaints of sleep disruption, while approximately 10 % have associated symptoms of daytime functional impairment. 1, 2, 3 • Sleep is an active physiological process: 1, 2, 3 • The metabolism slows down during sleep. • Major organs and regulatory functions continue to function. • The perfect duration is age-dependent: • Adults: 7 - 9 hours • Teenagers: ca. 9,5 hours • Infants: 16 hours • During sleep the body is able to repair itself.

  6. 3. Product information For restful nights and productive days

  7. 3. Product information For restful nights and productive days

  8. 4. Key benefits • Beneficialcombinationofvalerian, lemonbalm, hop, vitaminsand L-tryptophanthatsupportssleepquality. • Natural calmingeffectsfor strong nervesand mental resilience. • Rich in plant-basedingredients to avoiddependencyandhangovereffectsthefollowingday.

  9. 5. Target group People with emotional tension or exhaustion Business people that travel a lot Stressed persons Men and women over 60 years of age

  10. 6. Posology & administration INGREDIENTS * nodailyrequirementdataavailable INTAKE • 2capsules 30 - 60 minutesbeforebedtimewith a sufficientamountof fluid (ideallyonebigglassofwater). • To betakencontinuouslyforat least 2 weeks.

  11. 7. Ingredients L-Tryptophanis an essential amino acid that may improve sleep onset latency and sleep quality as it is a precursor of melatonin. Melatonin is a hormone that is secreted during the night and which is important for the regulation of the sleep-wake-cycle. 4 Valerianis a plant native to Europe and Asia. good night Denk contains valerian extract from dried roots, which has a sedating effect. It may improve sleep onset latency and sleep quality. 5, 6, 7 Lemon balm may have calming effects and thereby may relieve stress and may ameliorate insomnia. 8, 9 Hop acts in a similar way to melatonin, thus contributes to the regulation of sleep-wake-cycle. 10 Vitamin C contributes to normal functioning of the nervous system and to normal psychological function. 11 Niacincontributes to normal functioning of the nervous system and to normal psychological function. 11 L-Trypto- phan Valerian Lemon balm Hop Vitamin C Niacin

  12. 7. Ingredients L-Trypto- phan 4, 7 • Is an essential aminoacid. • Plays an importantrole in proteinbiosynthesis. • Is a precursoroftheneurotransmitterserotoninandthehormonemelatonin. Serotonin L-Tryptophan Melatonin

  13. 7. Ingredients • Serotonin 4, 7 • Is an important messenger substance within the body that acts by binding to certain receptors. • It is most commonly known as happiness hormone because it stimulates mood and relieves the body’s stress response. • It has also following effects: • relaxing • anti depressant • sleep inducing • Melatonin 4, 7 • Normally, melatonin is synthesized and released in response to increasing levels of darkness. • Its production is suppressed by light. • It promotes sleep and thus is designated as sleep hormone.

  14. 7. Ingredients Vitamin C • Contributes to normal functioningofthenervoussystemand to normal psychologicalfunction. 11 • Isnecessaryfortheconversionof L-Tryptophan to a precursorofserotonin (andthereforethesynthesisofmelatonin). Vitamin C L-Tryptophan Serotonin Melatonin

  15. 7. Ingredients Niacin Niacin • Contributes to normal functioningofthenervoussystemand to normal psychologicalfunction. 11 • Itis a vitaminand at the same time anotherdegradationproductof L-Tryptophan. • Itsaddition to goodnight Denk supportstheconversionof L-Tryptophan to melatoninasniacinitselfisalreadypresent. L-Tryptophan Serotonin Melatonin Niacin

  16. 7. Ingredients Valerian Valerian • Many chemical constituents of valerian have been identified, but it is not known which of them may be exactly responsible for the sleep-promoting effects. • It is likely that there is no single active compound and that valerian’s effects result from multiple constituents acting independently or synergistically. 5, 6, 7 Valerian root dried & cut

  17. 7. Ingredients Valerian • A possible mechanism by which valerian extract may cause sedation is by increasing the amount of gamma aminobutyric acid (GABA), an inhibitory neurotransmitter available in the synaptic cleft: with valerian: without valerian: inhibitory action inhibitory action GABA brain nerve endings brain nerve endings GABA-receptor synaptic cleft synaptic cleft • Valerian extract may cause GABA to be released from brain nerve endings and then block GABA from being taken back into nerve cells. 5, 6, 7

  18. 7. Ingredients Valerian Valerian (2 of 2) Valerian • To sum up, GABA reduces the activity of nerve cells in the brain. • Consequently, stress and anxiety signals reach their processing centers within the brain in reduced amount. • Valerian (and GABA) supports relaxing and falling asleep. • In addition, valerenic acid inhibits an enzyme that destroys GABA. This supports the sedating effects additionally. 5, 6, 7 The increased available quantity of the inhibitory neurotransmitter GABA in the synaptic cleft induces sedating effects.

  19. 7. Ingredients Lemon balm • It has calming effects and thereby relieves stress and ameliorates insomnia. • A number of possible active components of the dried leaf of lemon balm may be responsible for its calming effects - such as eugenol, citronellol or neral. • There are different suggestions regarding the reason for lemon balm’s calming effects (acetylcholine receptor, GABA receptor) but the exact mechanism is not conclusively clarified, yet. 9, 12, 13, 14, 15

  20. 7. Ingredients Hop • Orally, hop cones are used for example for anxiety, insomnia and other sleep disorders. • Apparently, hop acts on the brain similar to the sleep hormone melatonin by influencing sleep-wake-cycle and thus promoting sleep. • By now, it is not sufficiently known which substances are responsible for the sleep-inducing effects of hop cone. 16

  21. 8. Sleep-Wake-Cycle 12 • The Sleep-Wake-Cycle is composed of: 1, 2, 8 • 8 hours of nocturnal sleep • 16 hours of daytime wakefulness • The Sleep-Wake-Cycle and thus alertness level is controlled by two internal biological mechanisms which interact and balance each other: 3 9 6 Process C (Circadian rhythm) Process S (Sleep homeostasis) Wakefulness drive Sleep drive

  22. 8. Sleep-Wake-Cycle • WAKEFULNESS DRIVE (Process C) 1, 2, 8 • Refers to clinical changes that occur over a 24 hour period. • Governed by the brain’s biological clock. • External signals (light & dark) “set” the biological clock and prompt sleeping in the dark and being awake during daytime. awake asleep Process C (Circadian rhythm) Wakefulness drive 3 p.m. 9 p.m. 3 a.m. 9 a.m. 9 a.m.

  23. 8. Sleep-Wake-Cycle • SLEEP DRIVE (Process S) 1, 2, 8 • Accumulation of sleep-inducing substances throughout the waking period. • Increases the sleep drive throughout the waking period, regardless of whether it is day or night. This means that you become more and more tired by itself the longer you are awake. Sleep drive Process S (Sleep homeostasis) awake asleep 3 p.m. 9 p.m. 3 a.m. 9 a.m. 9 a.m.

  24. 8. Sleep-Wake-Cycle Alertness is regulated SIMULTANEOUSLYby sleep homeostasis and wakefulness drive: Sleep drive Process S (Sleep homeostasis) Alertness level supports a balanced Sleep-Wake-Cycle! Process C (Circadian rhythm) Wakefulness drive 3 p.m. 9 p.m. 3 a.m. 9 a.m. 9 a.m.

  25. 9. Insomnia - Background • Insomnia is a common sleep disorder that affects 30 % of the general population. Insomnia can be: 8 • temporary (up to 1 month due to e.g. jetlag, stress, major life changes) or • chronic (minimum 3 nights a week for a month or longer). • It is associated with difficulties concerning: 8 • falling asleep. • waking up during the night. • waking up too early. • not feeling well-rested after a night’s sleep. • daytime tiredness and sleepiness. • ongoing worries about sleep. • impaired health, work performance and quality of life. • difficulties paying attention, focusing on tasks and remembering.

  26. 9. Insomnia – Riskfactors • Female sex 1, 2, 8 • Hormonal shifts during the menstrual cycle and in menopause may play a role. • During menopause, night sweats and hot flashes often disrupt sleep. • Over 60 years 1, 2, 8 • Because of changes in sleep patterns and health, insomnia increases with age. • Physical health conditions 1, 2, 8 • Sleep can be disrupted by many different issues that impact mental or physical health.

  27. 9. Insomnia – Riskfactors • Stress 1, 2, 8 • Stressful times and events can cause temporary insomnia. • Major or long-lasting stress can be the reason for chronic insomnia. Stress • No regular schedule 1, 2, 8 • The sleep-wake-cycle can be disrupted for example by • Changing shifts at work. • Traveling with time changes. • Medications / medical conditions 1, 2, 8 • Many prescription drugs can interfere with sleep (e.g. antidepressants, medications for asthma or blood pressure) • Examples of conditions associated with insomnia include chronic pain, cancer, diabetes, heart disease, gastroesophageal reflux disease (GERD).

  28. 9. Insomnia – Riskfactors • Eating late 1, 2, 8 • Eating late may cause a physically uncomfortable feeling while laying down. • Many people also experience heartburn which may keep them awake. • Caffeine, nicotine and alcohol 1, 2, 8 • Coffee, tea, cola or other caffeinated drinks are stimulants that may prevent you from falling asleep. • Nicotine in tobacco products is another stimulant that can interfere with sleep. • Alcohol may help you fall asleep but it prevents deeper stages of sleep and often causes awakening in the middle of the night.

  29. 9. Insomnia - Complications Cognitive performance and mood Obesity & diabetes Immune function Hypertension Mental health disorders Source: 17, 18, 19, 20, 21

  30. 10. Good to know goodnight Denk should not beconsumedif you areallergic to valerian, melissa, hopconeoranyotheringredient. The use of good night Denk in childrenunder 12 years, pregnantorlactatingwomenis not recommended. Whentakingmedicines at the same time, a doctororpharmacistshouldbeconsultedaboutpossibleinteractions. 1. 2. 3.

  31. 11. Complementary treatment INDICATION: Sleep quality + • Calms nervous system. • Reduces chronic inflammatory stress levels. • Improves sleep quality.

  32. 12. Train the brain • Insomnia is a common sleep disorder in the general population. How many people are affected? • What is the perfect duration of sleep for adults? • What are the active ingredients contained in good night Denk? • How long should good night Denk at least be taken?

  33. 12. Train the brain • Insomnia is a common sleep disorder in the general population. How many people are affected? 30 % of the general population • What is the perfect duration of sleep for adults? 7-9 hours • What are the active ingredients contained in good night Denk? L-tryptophan, valerian extract, lemon balm extract, hop cone extract, vitamin C and niacin • How long should good night Denk at least be taken? 2 capsules 30 – 60 minutes before bedtime continuously for at least 2 weeks.

  34. [1] National Institutes of Health (2005): Manifestations and Management of Chronic Insomnia in Adults. 22 (2). [2] National Sleep Foundation (2006): Sleep-Wake Cycle: Its Physiology and Impact on Health. [3] National Sleep Foundation (2006): Sleep-Wake-Cycle. [4] Richard DM (2009): L-Tryptophan: Basic Metabolic Functions, Behavioral Research and Therapeutic Indications. Int J of Trp research. 2: 45-60. [5] Brattström A (2007): Scientific evidence for a fixed extract combination from valerian and hops. Med Wochenschr. 157: 367-370. [6] National Institutes of Health (2013): Valerian. [7] Mayo Clinic (2015): Valerian: A safe and effective herbal sleep aid? [8] Mayco Clinic (2016): Insomnia. [9] Cases J (2011): Pilot trial of Melissa officinalis L. leaf extract in the treatment of disturbances. Mediterr J NutrMetab. 4: 211-218. [10] Morin CM (2005): Valerian-hops combination. Sleep. 28(11): 1465-1471. [11] Commission européenne (2012) : règlement (UE) n° 432/2012. [12] Natural Medicines™ (2017): Lemon balm 13. References

  35. 13. References [13] Soulimani R, Fleurentin J, Mortier F, et al. Neurotropic action of the hydroalcoholic extract of Melissa officinalis in the mouse. Planta Med. 1991 Apr;57:105-9 [14] Kennedy DO, Scholey AB, Tildesley NT, et al. Modulation of mood and cognitive performance following acute administration of Melissa officinalis (lemon balm). PharmacolBiochemBehav 2002;72:953-64. [15] Kennedy DO, Wake G, Savelev S, et al. Modulation of mood and cognitive performance following acute administration of single doses of Melissa officinalis (Lemon balm) with human CNS nicotinic and muscarinic receptor-binding properties. Neuropsychopharmacology. 2003 Oct;28:1871-81. [16] Natural Medicines ™ (2017) Hop [17] Kuo AA (2001): Does sleep deprivation impair cognitive and motor performance as much as alcohol intoxication? West J Med. 174: 180-181. [18] Dement WC (1999): The promise of sleep. Delacorte Press. 274 [19] Spiegel K (2002): Effect of sleep deprivation on response to immunization. JAMA. 288(12): 1471-1472. [20] Spiegel K (1999): Impact of sleep debt on metabolic and endocrine function. Lancet. 453(9188):1435-1439.] [21] Rosansky SJ (1996): The relationship between sleep deprivation and the nocturnal decline of blood pressure, Am J Hypertens. 9(11): 1136-1138.]

  36. Join DenkPharma Our contributions to keeping you healthy: • affordable pharmaceuticals for your therapy • German high premium quality for tablets, sachets, packaging, studies, consultation, availability, support, etc… • raise awareness by conducting Check Up Days (blood glucose, blood pressure, cholesterol and triglyceride) • constantly enhancing the product portfolio

  37. HEALTHCARE MADE IN GERMANY since 1948

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