Anti-cholinergic Na+ channel blockade K+ channel blockade Alpha 1 antagonism Serotonin reuptake inhibition GABA antagonism. Anticholinergic toxidrome Wide QRS Prolonged QT Hypotension Seritonin syndrome Seizures. TCA mechanisms of Toxicity. Anticholinergic Toxidrome.
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Na+ channel blockade
K+ channel blockade
Alpha 1 antagonism
Serotonin reuptake inhibition
SeizuresTCA mechanisms of Toxicity
Dopamine stimulates the release of stored norepinephrine
Dopamine stimulates adrenergic receptorsTCAs and Hypotension
Cocaine and other sympathomimetics
Haldol and other neuroleptics
dfjklECG and Toxicology
Management?Case of the day!
Dip stick screen, immunoassay
HORRIBLE specificity thus the lab doesn’t even do it
Serum TCA levels
Do NOT correlate with toxicity
fldljfklTCA and lab testing