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Factors influencing release. size of drug particles. Factors influencing release. rate and extent of disintegration choice and conc’n of disintegrant. Factors influencing release. choice and conc’n of lubricant. compression pressure. Processing Problems. capping, lamination, chipping.

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Presentation Transcript
factors influencing release
Factors influencing release
  • size of drug particles
factors influencing release1
Factors influencing release
  • rate and extent of disintegration
    • choice and conc’n of disintegrant
factors influencing release2
Factors influencing release

choice and conc’n of lubricant

compression pressure

processing problems
Processing Problems
  • capping, lamination, chipping
processing problems1
Processing problems
  • sticking
  • mottling
  • weight and hardness variation
tablet evaluation
Tablet Evaluation
  • these tests are mandatory in the US and the procedures are outlined in the USP
    • dose uniformity
      • by weight variation
      • by content
    • disintegration
unofficial tests
Unofficial tests

mechanical strength

    • attrition resistance (friability)
    • fracture resistance
  • porosity
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