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Creams An introduction it is not

Creams An introduction it is not. Kausar Ahmad Kulliyyah of Pharmacy, IIUM. http://staff.iium.edu.my/akausar. Contents. Types of creams Mode of action Factors influencing efficacy. Manifestation of skin problem. Example of Cream for the treatment of eczema. http://www.freederm.com/.

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Creams An introduction it is not

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  1. CreamsAn introduction it is not Kausar Ahmad Kulliyyah of Pharmacy, IIUM http://staff.iium.edu.my/akausar PHM4153 Dosage Design 2 2010/11

  2. Contents Types of creams Mode of action Factors influencing efficacy PHM4153 Dosage Design 2 2010/11

  3. Manifestation of skin problem PHM4153 Dosage Design 2 2010/11

  4. Example of Cream for the treatment of eczema http://www.freederm.com/ CLAIMS: stops itching, heals and softens the skin, kills bacteria that causes irritation. PHM4153 Dosage Design 2 2010/11

  5. Considerations in Dosage Design Types of ailments e.g. Headache Cough Rashes Fever Cold Delivery route of medications e.g. • Oral • Ocular • Buccal • Percutaneous/Transdermal • Skin is barrier • CREAMS, gels, pastes, poultices PHM4153 Dosage Design 2 2010/11

  6. Cream PHM4153 Dosage Design 2 2010/11

  7. Ointment • ointment - a semisolid emulsion of oil and water, the main ingredient being oil • many topical drugs • specially formulated ophthalmic ointments • applied topically to the eye without causing irritation PHM4153 Dosage Design 2 2010/11

  8. Mode of action PHM4153 Dosage Design 2 2010/11

  9. PHM4153 Dosage Design 2 2010/11

  10. Drug dissolves, diffuse, release from vehicle Transepidermal partition./diffusion Transappendageal Pilosebaceous unit Eccrine/ apocrine gland Partition/ diffusion Partition/ diffusion Remove via circulation PHM4153 Dosage Design 2 2010/11

  11. Factors influencing efficacy • Diffusion through skin • Partition coefficient, pH, solubility….at the various layers of the skin • Can be modified by surfactants • Factors influencing absorption • Age, skin condition, drug/skin/vehicle interactions, temperature…… PHM4153 Dosage Design 2 2010/11

  12. e.g. Zinc cream BP (w/o) ZnO suspended in a w/o emulsion of peanut oil. The emulsifying agent is calcium oleateand wool fat. PHM4153 Dosage Design 2 2010/11

  13. e.g. W/O emulsifying agent • Wool fat • Wool alcohols • A fatty acid ester of sorbitan • The salt of a fatty acid • A divalent metal Ca++ • What is the HLB no. of above? PHM4153 Dosage Design 2 2010/11

  14. e.g. Aqueous cream BP 30% of emulsifying ointment with purified water preserved with chlorocresol. Boil and cool sufficient purified water. Measure the quantity required and dissolve the chlorocresol with the aid of gentle heat. Add solution to the melted emulsifying ointment. Stir gently until cold. PHM4153 Dosage Design 2 2010/11

  15. e.g. O/W emulsifying agents • Alkali salt of a fatty acid e.g. potassium oleate • PEG derivative of a sorbitan fatty acid ester • What is the HLB no of the above? PHM4153 Dosage Design 2 2010/11

  16. Ingredients of FreeDermHC • API • 1% hydrocortisone • Excipients • deionized water, • polawax • cetyl alcohol, stearyl alcohol, glycerylstearate, • dimethicone, propylene glycol, • methyl paraben, propylparaben, imidazolidinylurea, • benzylalkoniumchloride, • triethanolamine, • citric acid.  • What is the function of each ingredient above? PHM4153 Dosage Design 2 2010/11

  17. Conclusion Disadvantages • Incomplete • easily brushed off • Dose not known • Dose accuracy not maintained • Microbial growth if WATER is contaminated • Shorter shelf life compared to solid dosage forms Advantages Convenient Easy to administer Localised Immediate effect Prompt drug withdrawal Easy to manufacture PHM4153 Dosage Design 2 2010/11

  18. Exercise Describe the function of the following creams and identify the active ingredients: Ellgy Mecdema Sun Sense Fucidin Elomet PHM4153 Dosage Design 2 2010/11

  19. References Gennaro, A. R. (2000). Remington: The Science and Practice of Pharmacy 20th Ed. Philadelphia: Lippincott Williams and Wilkins. p 836-857 Ansel, H. C., Allen, V. & Poovich, N. G. (1999). Pharmaceutical dosage forms and drug delivery systems 7th Ed. Philadelphia: Lippincott Williams and Wilkins. p 244-262 Weiner, M. L. & Kotkoskie, L. A. (2000). Excipient Toxicity and Safety. New York: Marcel Dekker. Chapter 7 (Library: RS201) Magdassi ,S. & Touitou, E. (1999) . Novel Cosmetic Delivery Systems. New York: Marcel Dekker. Chap 9 (Librray: TP983.3) PHM4153 Dosage Design 2 2010/11

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