Arthritis. Clinical Quiz. DMARDs. Which drugs and how do they work?. Methotrexate. Folic acid antagonist → Cytotoxic, immunosuppressant. Sulfasalazine. Scavenger of toxic metabolites produced by neutrophils. Penicillamine. Immunosuppressant. Blocks IL-1 and collagen maturation. Gold.
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Which drugs and how do they work?
Folic acid antagonist → Cytotoxic, immunosuppressant
Scavenger of toxic metabolites produced by neutrophils
Immunosuppressant. Blocks IL-1 and collagen maturation
Blocks IL-1, TNF
What are the targets, and what effect rheumatic disease?
TNF → Anti inflammatory
CD20 → Anti B Cell
Clinical diagnosis requires ≥ 4 of these 7:
Standing radiograph of the knee reveals narrowing of the medial and lateral femorotibial compartments with marginal osteophytes.
Multiple erosions with deformity of the carpal bones in a patient with rheumatoid arthritis of the hands.
Hip joint changes. Frontal radiograph shows uniform joint space narrowing and a collar of osteophytes at the femoral head-neck junction. Left sacroiliac joint ankylosis is present.