The Growing Problem of Antibiotic Resistance. 张驰 王昳楠. Have we conquered bacteria yet?. Why the pharmaceutical industry has cut resources devoted to the development of new antibiotics. Lack of financial incentives Short lifetime in the marketplace
Sulfa drugs, are effective antibiotics because they closely resemble the compound p-aminobenzoic acid (PABA)
Penicillin is a β-lactam; that is, it contains a four- membered β-lactam ring (shown in color).
—— not only among the cells of a given species, but also between species
DNA is passed from one bacterial cell to another
a bacterial gene is carried from cell to cell by a virus
a bacterial cell is able to pick up naked DNA
from its surrounding medium
Not all penicillin-resistant bacteria have acquired aβ–lactamase gene.