1 / 6

Different types of centralities in Metabolic Network

Different types of centralities in Metabolic Network.

leone
Download Presentation

Different types of centralities in Metabolic Network

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. Different types of centralities in Metabolic Network

  2. There are various measures of the centrality of a vertex within a graph that determine the relative importance of a vertex within the graph (for example, how important a compond is within a metabolic network, or how important a pathway is within a metabolic network). • There are four measures of centrality that are widely used in network analysis: • degree centrality, • betweenness, • closeness, • eigenvector centrality.

  3. Degree centrality • Degree centrality is defined as the number of links incident upon a node . If the network is directed (meaning that ties have direction), then we usually define two separate measures of degree centrality, namely indegree and outdegree. • Indegree is a count of the number of directed edges to the node, and outdegree is the number of edges of that node directs to others. • For positive relations such as friendship or advice, we normally interpret indegree as a form of popularity, and outdegree as gregariousness.

  4. Betweennessis a centrality measure of a vertex within a graph . Vertices that occur on many shortest paths between other vertices have higher betweenness than those that do not. • Closeness centrality : • Vertices that are 'shallow' to other vertices (that is, those that tend to have short distances to other vertices with in the graph) have higher closeness. • Closeness is preferred in network analysis to mean shortest-path length, as it gives higher values to more central vertices, and so is usually positively associated with other measures such as degree.

  5. Eigenvector centrality: is a measure of the importance of a node in a network. • It assigns relative scores to all nodes in the network based on the principle that connections to high-scoring nodes contribute more to the score of the node in question than equal connections to low-scoring nodes.

  6. D-fructose-6-phosphate and glyceraldehyde-3-phosphate which are intermediates in the glycolysis pathway; • D-ribose-5-phosphate and xylulose-5-phosphate which are intermediates in the pentose pathway and acetyl-CoA which is the metabolite linking glycolysis pathway, citric acid cycle and fatty acid synthesis pathway. • 5-Phospho-D-ribose 1-diphosphate, the precursor for purine and histidine synthesis, is also within the first ten hub metabolites. • This result indicates that topological analysis of metabolic networks could reveal the evolution history .

More Related