What are dendritic cells and what do they do?. Play movie. Dendritic cells. Highly professional antigen presenting cells DC reside in the peripheral tissues Upon exposure to antigen they migrate to the lymphoid organs via the lymphatics
Initially identified as axonal guidance cues that determine the direction and migration of neurons.
Their discovery was in regards to axon guidance in the limb buds of grasshoppers in 1992
subsequently found to be involved in many other systems.
Plexin-A1 is a receptor for semaphorin 3A and semaphorins 6C and 6D.
All are expressed in lymphatic endothelial cells
Plexin-A1 binds to Sem3A in association with NRP-1
Sem3A is soluble
Sem6C and Sem6D are both transmembrane molecules
Wildtype DCs were transferred into Sem3A -/-, Sem6C -/- and Sem 6D -/- mice.
Presence of DCs in draining lymph nodes estimated