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The MIN mouse : (1.) Heterozygous for the highly penetrant Apc Min allele. PowerPoint Presentation
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The MIN mouse : (1.) Heterozygous for the highly penetrant Apc Min allele. - PowerPoint PPT Presentation


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The MIN mouse : (1.) Heterozygous for the highly penetrant Apc Min allele. (2.) Min/Min homozygotes die at gastrulation. (3.) Mice develop numerous (50-200) adenomas in the small intestine, and few (0-3) in the colon. (4.) Death occurs around 5 months of age.

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PowerPoint Slideshow about 'The MIN mouse : (1.) Heterozygous for the highly penetrant Apc Min allele.' - leigh-simpson


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slide2

The MIN mouse:

(1.) Heterozygous for the highly penetrant ApcMin allele.

(2.) Min/Min homozygotes die at gastrulation.

(3.) Mice develop numerous (50-200) adenomas in the small intestine, and few (0-3) in the colon.

(4.) Death occurs around 5 months of age.

(5.) Tumor multiplicity modulated by genetic background, drugs, and diet.

slide3

wnt

frizzled

dsh

E-cadherin

-catenin

P

slimb

-catenin

GSK3

-catenin

conductin/axin

APC

-catenin

LEF/ TCF

-catenin

LEF/ TCF

Target Genes

slide14

Treated

(Tomudex 5mg/kg)

Folate-deficient diet

Untreated

slide15

Does the genetic character of stromal (i.e., bone marrow-derived) cells determine response to anti-neoplastic agents?

slide16

The role of the tumor stroma in conferring response

to TS inhibitors.

Marrow response

to drug ex vivo

Introduce TS gene

Transplant

Tumor response

to drug therapy

MIN Recipient

eGFP Donor

Bone Marrow

Therapeutic toxicity