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HEMATOLOGY. ABNORMAL LEUKOCYTES AND ERYTHROCYTES. ROULEAUX. ROULEAUX ARE ERYTHROCYTES ARRANGED IN ROW LIKE STACK OF COINS . ROULEAUX ARE ASSOCIATED WITH INCREASED CONCENTRATIONS OF GLOBULINS AND PARAPROTEINS. DISEASE CORRELATION: MULTIPLE MYLOMA. ACANTHOCYTE.

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hematology

HEMATOLOGY

ABNORMAL LEUKOCYTES AND ERYTHROCYTES

rouleaux
ROULEAUX

ROULEAUX ARE ERYTHROCYTES ARRANGED IN ROW LIKE STACK OF COINS . ROULEAUX ARE ASSOCIATED WITH INCREASED CONCENTRATIONS OF GLOBULINS AND PARAPROTEINS.

DISEASE CORRELATION: MULTIPLE MYLOMA

acanthocyte
ACANTHOCYTE

ACANTHOCYTES ARE ERYTHROCYTES WITH IRREGULARLY SPACED PROJECTIONS THAT VERY IN WIDTH, LENGTH, AND NUMBER DUE TO LIPID IMBALANCE.

ASSOCIATED WITH ABETALIPOPROTEINEMIA, SEVERE LIVER DISEASE, SPLENECTOMY, MALABSORPTION, HYPOTHYROIDISM, VITAMIN E DEFICIENCY.

echinocyte
ECHINOCYTE

CRENATED ERYTHROCYTE WITH SHORT, EVENLY SPACED PROJECTIONS FORMED DURING CELLULAR DEHYDRATION MAY BE REVESIBLE.

ASSOCIATED WITH UREMIA, PYRUVATE KINASE DEFICIENCY, MICROANGIOPATHIC HEMOLITIC ANEMIA.

hypochromia
HYPOCHROMIA

IT IS CONSIDERED HYPOCHROMIA WHEN THE CENTRAL PALLOR ZONE OF THE ERYTHROCYTE IS GREATER THAN ONE THIRD OF THE DIAMETER OF THE CELL.

ASSOCIATED WITH IRON DEFICIENCY ANEMIA, THALASSEMIAS, SIDEROBLASTIC ANEMIA, LEAD POISONING, AND SOME CASES OF CHRONIC DISEASE.

elliptocyte
ELLIPTOCYTE

ELLIPTOCYTES ARE CIGAR-SHAPED ERYTHROCYTE DUE TO MEMBRANE DISORDER.

ASSOCIATED WITH HERIDITARY ELLIPTOCYTOSIS , THALASSEMIA MAJOR, IRON DEFICIENCY ANEMIA, MEGALOBLASTIC ANEMIAS, AND MYELOPHTHISIC ANEMIAS.

myeloblast
MYELOBLAST

LEAST DIFFERENTIATED BONE MARROW PRECURSOR OF THE GRANULOCYTIC SERIES.

SIZE OF 15-20 um WITH A ROUND TO OVAL NUCLEUS AND VISIBLES NUCLEOLI, FINE CHROMATIN AND MODERATE BASOPHILIC CYTOPLASM.

MYELOBLAST CORRELATED WITH ACUTE LEUKEMIA.

myelocyte
MYELOCYTE

THIRD STAGE OF BONE MARROW GRANULOCYTE SERIES DIFFERENTIATION

SIZE 12-18 um WITH A ROUND TO OVAL NUCLEUS MAY HAVE A FLATTENED SIDE.

IN THIS STAGE DIFFERENTIATION OF CYTOPLASMIC GRANULES MAY BECOME BASOPHILIC, EOSINOPHILIC, OR NEUTROPHILIC.

THE PRESENCE OF ANY PRECURSOR IN THE PERIPHERAL BLOOD SIGNALS ACUTE LEUKEMIA.

slide9
BAND

IMMEDIATED PRECURSOR OF THE MATURE SEGMENTED NEUTROPHIL. BAND ARE PRESENT IN THE BONE MARROW AND PERIPHERAL BLOOD THE PROBLEM IS WHEN AN EXCESSIVE BANDS MORE THAN 10 % SHOWS IN THE BLOOD STREAM CAN BE THE SIGN OF HYPERPROLIFERATIVE BONE MARROW.

hypersegmented neutrophil
HYPERSEGMENTED NEUTROPHIL

NEUTROPHIL WITH FIVE ,SIX OR MORE SEGMENTS; OFTEN ASSOCIATED WITH MEGALOBLASTIC ANEMIA.

giant platelet
GIANT PLATELET

IT IS CONSIDERED A GIANT PLATELET WHEN IS GREATER THAN AN RBC

ASSOCIATED WITH BERNARD-SOULIER SYNDROME THIS IS AN ADHESION DISORDER.