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Blood Vessels

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Blood Vessels

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    1. Blood Vessels

    3. Vasculitides = Inflammation of Blood Vessels Present with Non-Specific/ systemic/Vague complaints Fever, Myalgia, Artharlgia, Malaise, etc., Pathogenic Mechanisms Immune – MCC 1. Immune complex = Hypersensitivity (to Drugs), Following Viral Infections (PAN & HBV) 2. ANCA Positive (Anti Neutrophil Cytoplasmic Antibody) C- ANCA (Ab Against Proteinase -3) = Wagener's P- ANCA ( Ab against MPO) = mPAN, Chaurg – Straus 3. Anti – Endothelial Cell = SLE, Kawasaki’s Infectious – Less Common, Direct Trauma is the cause, can be Bacterial or fungal

    4. Vasculitides = Types Based on Size of Vessels involved Site of involvement Characteristic Features 1. Giant Cell ( Temporal ) Arteritis Systemic Vasculitis Sites = Temporal ( Head ache & Facial Pain), Vertebral, Ophthalmic ( Blindness), Aorta ( Aneurysm) Age, Sex & Ethnicity = >50 yrs., M=F, Nordic people Clinical = Facial Pain & Headache, Diplopia & Blindness (most dangerous, Sudden, permanent) Pathology / Morphology = Granulomas in vessel walls, Giant cells, Segmental involvement Diagnosis = Biopsy is important Treatment = Steroids save vision

    5. 1. Giant Cell ( Temporal ) Arteritis Systemic Vasculitis Sites = Temporal ( Head ache & Facial Pain), Vertebral, Ophthalmic ( Blindness), Aorta ( Aneurysm) Age, Sex & Ethnicity = >50 yrs., M=F, Nordic people Clinical = Facial Pain & Headache, Diplopia & Blindness (most dangerous, Sudden, permanent) Pathology / Morphology = Granulomas in vessel walls, Giant cells, Segmental involvement, Fragmentation of Internal Elastic Lamina (IEL) Diagnosis = Biopsy is important Treatment = Steroids save vision

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