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This study explores how autoreactive T cells can stimulate B cells to produce ACPA in rheumatoid arthritis (RA) patients. It discusses the impact of ACPA status and characteristics on the course of RA.
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Figure 1ACPA production by B cells can be stimulated by autoreactive T cells Willemze, A. et al. (2012) The influence of ACPA status and characteristics on the course of RA Nat. Rev. Rheumatol. doi:10.1038/nrrheum.2011.204